Epithelioid hemangioendothelioma in children: The European Pediatric Soft Tissue Sarcoma Study Group experience

被引：3

作者：

Orbach, Daniel ^{[1
]}

Van Noesel, Max M. ^{[2
,3
]}

Brennan, Bernadette ^{[4
]}

Corradini, Nadege ^{[5
]}

Alaggio, Rita ^{[6
]}

Ben Arush, Myriam ^{[7
]}

Schoot, Reineke A. ^{[2
,3
]}

Berlanga, Pablo ^{[8
]}

Zanetti, Ilaria ^{[9
]}

Hjalgrim, Lisa Lyngsie ^{[10
]}

Di Corti, Federica ^{[11
]}

Ramirez, Gema ^{[12
]}

Casanova, Michela ^{[13
]}

Ferrari, Andrea ^{[13
]}

机构：

[1] PSL Univ, Inst Curie, Care Innovat & Res Children Adolescents & Young A, SIREDO Oncol Ctr Care, Paris, France

[2] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Div Canc & Imaging, Utrecht, Netherlands

[4] Royal Manchester Childrens Hosp, Paediat Oncol, Manchester, Lancs, England

[5] Leon Berard Ctr, IHOPe, Dept Pediat Hematol & Oncol, Lyon, France

[6] Osped Pediat Bambino Gesu IRCCS, Pathol Dept, Rome, Italy

[7] Ruth Rappaport Childrens Hosp, Haifa, Israel

[8] Univ Paris Saclay, Gustave Roussy Canc Campus, Dept Pediat & Adolescent Oncol, Villejuif, France

[9] Padova Univ Hosp, Dept Womens & Childrens Hlth, Haematol Oncol Div, Padua, Italy

[10] Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark

[11] Univ Hosp Padua, Women & Childrens Hlth Dept, Pediat Surg, Padua, Italy

[12] Pediat Hosp Virgen del Rocio, Pediat Oncol & Hematol, Seville, Spain

[13] Fdn IRCCS Ist Nazl Tumori, Pediat Oncol Unit, Milan, Italy

来源：

PEDIATRIC BLOOD & CANCER | 2022年 / 69卷 / 10期

关键词：

children; hemangioendothelioma; soft tissue sarcoma; surgery;

D O I：

10.1002/pbc.29882

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The European pediatric Soft tissue sarcoma Study Group analyzed all children with epithelioid hemangioendothelioma prospectively registered in the NRSTS-05 (EUDRACT 2005-001139-31) and in MTS-2008 (NCT00379457) studies: 10 patients with localized and one with metastatic disease. Median age was 14.3 years (range, 9.0-18.8). Local therapy was initial primary surgery in seven cases, and five patients received systemic therapy. No patients received radiotherapy. After a median follow-up of 50 months (range, 6-176) for living patients, nine patients remain alive off therapy and two died. Five-year progression free and overall survivals are, respectively, 77.1% (95% confidence interval [CI]: 34.5-93.9) and 74.1% (95% CI: 28.1-93.0).

引用

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