mSphere of Influence: Structural Insights into the Molecular Mechanism Underlying Placental Malaria

被引：1

作者：

Quintana, Maria del Pilar ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Immunol & Microbiol, Ctr Med Parasitol, Copenhagen, Denmark

来源：

MSPHERE | 2021年 / 6卷 / 03期

关键词：

Plasmodium falciparum; placental malaria; VAR2CSA structure; vaccine; CHONDROITIN SULFATE; ANTIBODIES; BINDING; DOMAINS; ADHESION; GENE;

D O I：

10.1128/mSphere.00391-21

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Maria del Pilar Quintana works on immunology and pathogenesis of severe malaria. In this mSphere of Influence article, she reflects on how the papers "Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA" (R. Ma, T. Lian, R. Huang, J. P. Renn, J. D. Petersen, J. Zimmerberg, P. E. Duffy, N. H. Tolia, Nat Microbiol 6:380-391, 2021, https://doi.org/10.1038/s41564-020-00858-9) and "Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding" (K. Wang, R. Dagil, T. Lavsten, S. K. Misra, C. B. Spliid, Y. Wang, T. Gustavsson, D. R. Sandoval, E. E. Vidal-Calvo, S. Choudary, M. O. Agerback, K. LindorffLarsen, M. A. Nielsen, T. G. Theander, J. S. Sharp, T. M. Clausen, P. Gourdon, A. Salanti, Nat Commun 12:2956, 2021, https://doi.org/10.1038/s41467-021-23254-1) shed light on the precise structural details behind Plasmodium falciparum VAR2CSA binding to chondroitin sulfate A (CSA) in the placenta and how these novel insights have changed the way she will approach her work toward the discovery of new broadly cross-reactive/inhibitory antibodies targeting VAR2CSA.

引用

页数：4

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