Retrospective Analysis of Growth Speed of 54 Lesions of Colitis-associated Colorectal Neoplasia

被引：0

作者：

Yamasaki, Kazutomo ^{[1
]}

Matsui, Toshiyuki ^{[1
]}

Hisabe, Takashi ^{[1
]}

Yano, Yutaka ^{[1
]}

Hirai, Fumihito ^{[1
]}

Morokuma, Tsuyoshi ^{[1
]}

Iwao, Yasushi ^{[2
]}

Matsumoto, Takayuki ^{[3
]}

Ohi, Hidehisa ^{[4
]}

Andoh, Akira ^{[5
]}

Esaki, Motohiro ^{[6
]}

Aoyagi, Kunihiko ^{[7
]}

Sugita, Akira ^{[8
]}

Nakase, Hiroshi ^{[9
]}

Fujiya, Mikihiro ^{[10
]}

Higashi, Daijiro ^{[11
]}

Futami, Kitaro ^{[11
]}

机构：

[1] Fukuoka Univ, Dept Gastroenterol, Chikushi Hosp, 1-1-1 Zokumyoin, Chikushino, Fukuoka 8188502, Japan

[2] Keio Univ Hosp, Ctr Prevent Med, Tokyo, Japan

[3] Iwate Med Univ, Div Gastroenterol, Dept Internal Med, Morioka, Iwate, Japan

[4] Imamura Hosp, Dept Gastroenterol, Kagoshima, Japan

[5] Shiga Univ Med Sci, Fac Med, Otsu, Shiga, Japan

[6] Kyushu Univ, Dept Med & Clin Sci, Fukuoka, Japan

[7] Fukuoka Univ, Sch Med, Dept Internal Med 3, Fukuoka, Japan

[8] Yokohama Municipal Citizens Hosp, Yokohama, Kanagawa, Japan

[9] Kyoto Univ, Div Endoscop Med, Dept Gastroenterol & Hepatol, Kyoto, Japan

[10] Asahikawa Med Coll, Dept Med, Asahikawa, Hokkaido, Japan

[11] Fukuoka Univ, Chikushi Hosp, Dept Gastroenterol Surg, Chikushino, Fukuoka 8188502, Japan

来源：

ANTICANCER RESEARCH | 2016年 / 36卷 / 07期

关键词：

Ulcerative colitis; colitis-associated colorectal neoplasia (CRN); initial lesion; INFLAMMATORY-BOWEL-DISEASE; STANDING ULCERATIVE-COLITIS; POPULATION-BASED COHORT; SURVEILLANCE COLONOSCOPY; CANCER SURVEILLANCE; RISK-FACTOR; DYSPLASIA; METAANALYSIS; PROGRAM;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: This study used a multicenter questionnaire survey to evaluate the morphology and progression of the initial lesion in cases of colitis-associated colorectal neoplasia (CRN). Patients and Methods: Endoscopic images of lesions that had been definitively diagnosed as CRN by pathological examination were retrospectively reviewed. Results: This resulted in the identification of 54 initial lesions in 49 patients. The 54 initial lesions fell into the following categories: 22 endoscopically visible localized lesions consisting of 18 elevated lesions and 4 depressed lesions, as well as 32 lesions that were not endoscopically visible as localized and consisted of 20 active-phase mucosal lesions and 12 remission-phase mucosal lesions. Nineteen of the lesions eventually became advanced cancers, while 35 lesions eventually became early-stage cancers. The final lesions were 40 elevated lesions, 5 flat or depressed lesions and 9 stenotic lesions. The form of growth of the advanced cancers was progressive stenosis or increased elevation. For approximately 69% of the early-stage cancers, the growth form was increasing elevation or development of elevation. For 73.6% of the advanced cancers, the initial lesion underwent rapid growth and became advanced cancer within 3 years; they accounted for 25.9% of the total cancers. Approximately 40% of the initial lesions of CRN were endoscopically visible as localized lesions, while approximately 60% were judged to be inflammatory mucosal lesions. Conclusion: It will be necessary to proactively take biopsy inflammatory mucosal lesions in order to discover tumors early and periodic surveillance should be performed with the knowledge that tumors may grow very quickly.

引用

页码：3731 / 3740

页数：10

共 24 条

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