Facile one-pot synthesis of novel 3-substituted-1, 6-dihydro-1,2,4-triazin-5-(2H)-ones from fatty acid hydrazides and their in-vitro antimicrobial activity

被引：0

作者：

Farshori, Nida Nayyar ^{[1
]}

Banday, Mudasir Rashid ^{[1
]}

Ahmad, Anis ^{[2
]}

Khan, Asad Ullah ^{[2
]}

Rauf, Abdul ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Dept Chem, Aligarh 202002, Uttar Pradesh, India

[2] Aligarh Muslim Univ, Biotechnol Unit, Aligarh 202002, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2011年 / 50卷 / 04期

关键词：

Fatty acid hydrazides; 1,2,4-triazin-5-ones; IR; (1)H NMR; MS; antimicrobial activity; TRANSITION-METAL-COMPLEXES; NITROGEN SYSTEMS BEARING; PART III; (L)-3-ACETYL-5-BENZYL-1-PHENYL-4,5-DIHYDRO-1,2,4-TRIAZIN-6-ONE OXIME; STRUCTURAL-CHARACTERIZATION; 1,2,4-TRIAZINE MOIETY; ANTICANCER DRUGS; IV; ANTIBACTERIAL; HETEROCYCLES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 3-substituted-1,6-dihydro-1,2,4-triazin-5(2H)-ones, have been synthesized using the cyclocondensation reaction of fatty acid hydrazides with 2-chloroacetamide. in N,N-dimethylformamide medium: The structural elucidation of the synthesized compounds is based oil IR, (1)H NMR, mass spectral data and elemental analysis. These compounds have been tested for their in-vitro antibacterial and antifungal activities. The MIC, MBC and MFC have also been determined.

引用

页码：605 / 610

页数：6

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