Intramuscular hepatitis B immunoglobulins for reinfection control after liver transplantation: a cost-saving alternative

被引：2
|
作者：
Hulstaert, Eva [1 ]
Verhelst, Xavier [1 ]
Geerts, Anja [1 ]
Van Vlierberghe, Hans [1 ]
机构：
[1] Univ Hosp Ghent, Dept Hepatol, B-9000 Ghent, Belgium
来源：
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2015年 / 4卷 / 03期
关键词：
comparative effectiveness; hepatitis B immunoglobulins; hepatitis B; liver transplantation; IMMUNE GLOBULIN; SURFACE-ANTIGEN; VIRUS INFECTION; PROPHYLAXIS; RECURRENCE; LAMIVUDINE; PREVENTION; MANAGEMENT; IMPACT; SAFE;
D O I：
10.2217/cer.15.4
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
Aim: We explore the effectiveness and cost-effectiveness of intramuscular versus intravenous hepatitis B immunoglobulins (HBIG-IV vs HBIG-IM) to prevent reinfection with the hepatitis B virus after orthotopic liver transplantation. Patients & methods: Overall, 14 patients had orthotopic liver transplantation in 2003-2013 at Ghent University Hospital for HBV-related liver disease. On average 32 months after transplantation patients switched from high-dose HBIG-IV to low-dose HBIG-IM, always in combination with a nucleos(t)ide analog. Results: Seven patients were switched so far. No significant differences between HBIG-IV and HBIG-IM were found in HBsAg and hepatitis B virus-DNA. Conclusion: Switching patients from HBIG-IV to HBIG-IM can be done safely if well monitored. Net yearly savings for the healthcare payer were Euro5000 for each patient switched to HBIG-IM.
引用
收藏
页码：259 / 265
页数：7
相关论文
共 50 条
  • [1] Pharmacokinetics and efficacy of intravenous or intramuscular hepatitis B immunoglobulins in prophylaxis of hepatitis B after liver transplantation
    Marzano, A.
    Marengo, A.
    Andreone, P.
    Volpes, R.
    Canova, D.
    Cursaro, C.
    Riili, A.
    Fiorentino, B.
    Bacci, M.
    Guazzini, S.
    Burra, P.
    MINERVA MEDICA, 2010, 101 (06) : 373 - 383
  • [2] Recommendations for Hepatitis B Immunoglobulin and Antiviral Prophylaxis Against Hepatitis B Recurrence After Liver Transplantation
    Akarsu, Mesut
    Onem, Soner
    Turan, Ilker
    Adali, Gupse
    Akdogan, Meral
    Akyildiz, Murat
    Aladag, Murat
    Balaban, Yasemin
    Danis, Nilay
    Dayangac, Murat
    Gencdal, Genco
    Gokcan, Hale
    Sertesen, Elif
    Gurakar, Merve
    Harputluoglu, Murat
    Kabacam, Gokhan
    Karademir, Sedat
    Kiyici, Murat
    Idilman, Ramazan
    Karasu, Zeki
    TURKISH JOURNAL OF GASTROENTEROLOGY, 2021, 32 (09) : 712 - 719
  • [3] Prevention of hepatitis B virus reinfection after orthotopic liver transplantation
    Zheng-Xin Wang
    Hepatobiliary & Pancreatic Diseases International, 2004, (03) : 345 - 348
  • [4] Hepatitis B immunoglobulins and/or lamivudine for preventing hepatitis B recurrence after liver transplantation: A systematic review
    Chen, Jie
    Yi, Liping
    Jia, Ji Dong
    Ma, Hong
    You, Hong
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2010, 25 (05) : 872 - 879
  • [5] Outcomes of Long-Term Administration of Intravenous Hepatitis B Immunoglobulins for the Prevention of Recurrent Hepatitis B After Liver Transplantation
    Pauwelyn, K.
    Cassiman, D.
    Laleman, W.
    Verslype, C.
    Monbaliu, D.
    Aerts, R.
    Van Steenbergen, W.
    Pirenne, J.
    Nevens, F.
    TRANSPLANTATION PROCEEDINGS, 2010, 42 (10) : 4399 - 4402
  • [6] Lamivudine and low-dose hepatitis B immune globulin for prophylaxis of hepatitis B reinfection after liver transplantation -: possible role of mutations in the YMDD motif prior to transplantation as a risk factor for reinfection
    Rosenau, J
    Bahr, MJ
    Tillmann, HL
    Trautwein, C
    Klempnauer, J
    Manns, MP
    Böker, KHW
    JOURNAL OF HEPATOLOGY, 2001, 34 (06) : 895 - 902
  • [7] Low-dose anti-hepatitis B immunoglobulin regimen as prophylaxis for hepatitis B recurrence after liver transplantation
    Lee, Wei-Chen
    Chou, Hong-Shiue
    Wu, Tsung-Han
    Cheng, Chih-Hsien
    Lee, Chen-Fang
    Wang, Yu-Chao
    Wu, Ting-Jung
    Chan, Kun-Ming
    TRANSPLANT INFECTIOUS DISEASE, 2019, 21 (06)
  • [8] The role of HBIg as hepatitis B reinfection prophylaxis following liver transplantation
    Mehrabi, Arianeb
    Esmaeilzadeh, Majid
    Fonouni, Hamidreza
    Hafezi, Mohammadreza
    Rahbari, Nuh N.
    Golriz, Mohammad
    Majlesara, Ali
    Rad, Morva Tahmasbi
    Sadeghi, Mahmoud
    Schmidt, Jan
    Ganten, Tom M.
    LANGENBECKS ARCHIVES OF SURGERY, 2012, 397 (05) : 697 - 710
  • [9] Cost-effective and safe ambulatory long-term immunoprophylaxis with intramuscular instead of intravenous hepatitis B immunoglobulin to prevent reinfection after orthotopic liver transplantation
    Faust, D
    Rabenau, HF
    Allwinn, R
    Caspary, WF
    Zeuzem, S
    CLINICAL TRANSPLANTATION, 2003, 17 (03) : 254 - 258
  • [10] Efficacy and Safety of Lamivudine or Tenofovir Plus Intramuscular Hepatitis B Immunoglobulin in Prevention of Hepatitis B Virus Reinfection After Liver Transplant
    Nassiri-Toosi, Mohssen
    Kasraianfard, Amir
    Ahmadinejad, Zahra
    Dashti, Habibollah
    Moini, Majid
    Najafi, Atabak
    Salimi, Javad
    Jafarian, Ali
    EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 2015, 13 : 127 - 132
12345