The role of ubiquitination and deubiquitination in tumor invasion and metastasis

被引：114

作者：

Han, Shuangze ^{[1
]}

Wang, Ruike ^{[1
]}

Zhang, Yangnan ^{[1
]}

Li, Xiaoying ^{[1
]}

Gan, Yu ^{[1
]}

Gao, Feng ^{[3
]}

Rong, Pengfei ^{[1
,2
]}

Wang, Wei ^{[1
,2
]}

Li, Wei ^{[1
,2
]}

机构：

[1] Cent South Univ, Dept Radiol, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China

[2] Cent South Univ, Cell Transplantat & Gene Therapy Inst, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China

[3] Cent South Univ, Dept Ultrasonog, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2022年 / 18卷 / 06期

关键词：

ubiquitination; E3 ubiquitin ligase; deubiquitinase; metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; CELL CARCINOMA METASTASIS; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; TERMINAL HYDROLASE-L1; RHO-GTPASES; PROMOTES; PROLIFERATION; TUMORIGENESIS; DEGRADATION;

D O I：

10.7150/ijbs.69411

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis. This review will briefly summarize the observations and underlying mechanisms of multiple E3 ubiquitin ligases and deubiquitinases to regulate tumor metastasis. Further, we will discuss the relationship and importance between ubiquitination components and tumor progression.

引用

页码：2292 / 2303

页数：12

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