Treatment of Severe Fungal Keratitis With Subconjunctival Amphotericin B

被引：21

作者：

Alejandra Carrasco, Maria ^{[1
]}

Genesoni, Graciela ^{[2
]}

机构：

[1] Hosp I Perrupato, Dept Ophthalmol, Mendoza, Argentina

[2] Hosp I Perrupato, Dept Microbiol, Mendoza, Argentina

来源：

CORNEA | 2011年 / 30卷 / 05期

关键词：

fungal keratitis; amphotericin B; subconjunctival injection; antifungal treatment; corneal ulcer; CORNEAL ULCERS; INJECTION; ENDOPHTHALMITIS; EYE;

D O I：

10.1097/ICO.0b013e3181fb826d

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To report the beneficial properties of subconjunctival amphotericin B as an adjunctive therapy in patients with severe fungal keratitis. Methods: Case reports and review of medical literature. Four patients with advanced fungal keratitis were treated with repeated injections of subconjunctival amphotericin B in addition to topical and systemic antifungal treatment. Results: Two to 8 injections were given to each patient. All patients showed rapid clinical improvement after the injections. No serious adverse effects were observed. However, all patients experienced pain during the injections. Conclusions: Subconjunctival injections of amphotericin B are useful as an adjunctive treatment of advanced fungal keratitis. This treatment assures compliance and may be an alternative to avoid a surgical intervention in an acute stage of advanced fungal keratitis. More cases are needed to validate our findings.

引用

页码：608 / 611

页数：4

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