Proteome Profiling Uncovers an Autoimmune Response Signature That Reflects Ovarian Cancer Pathogenesis

被引：9

作者：

Kobayashi, Makoto ^{[1
]}

Katayama, Hiroyuki ^{[1
]}

Irajizad, Ehsan ^{[2
]}

Vykoukal, Jody V. ^{[1
]}

Fahrmann, Johannes F. ^{[1
]}

Kundnani, Deepali L. ^{[1
]}

Yu, Chuan-Yih ^{[1
]}

Cai, Yining ^{[1
]}

Hsiao, Fu Chung ^{[1
]}

Yang, Wei-Lei ^{[3
]}

Lu, Zhen ^{[3
]}

Celestino, Joseph ^{[4
]}

Long, James P. ^{[2
]}

Do, Kim-Ann ^{[2
]}

Lu, Karen H. ^{[4
]}

Ladd, Jon J. ^{[5
]}

Urban, Nicole ^{[5
]}

Bast, Robert C. ^{[3
]}

Hanash, Samir M. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, 1515 Holcombe Blvd, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Biostat, 1515 Holcombe Blvd, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, 1515 Holcombe Blvd, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol & Reprod Med, 1515 Holcombe Blvd, Houston, TX 77030 USA

[5] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci, Translat Res Program, 1100 Fairview Ave N, Seattle, WA 98109 USA

来源：

CANCERS | 2020年 / 12卷 / 02期

关键词：

ovarian cancer; autoantibody signature; TP53-MYC network; antigen-antibody complexes; POLYADENYLATION REGULATORY ELEMENTS; LUNG-CANCER; POOR-PROGNOSIS; BREAST-CANCER; P53; ANTIBODY; AUTOANTIBODY; IDENTIFICATION; BIOMARKERS; RECOGNITION; DIAGNOSIS;

D O I：

10.3390/cancers12020485

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Harnessing the immune response to tumor antigens in the form of autoantibodies, which occurs early during tumor development, has relevance to the detection of cancer at early stages. We conducted an initial screen of antigens associated with an autoantibody response in serous ovarian cancer using recombinant protein arrays. The top 25 recombinants that exhibited increased reactivity with cases compared to controls revealed TP53 and MYC, which are ovarian cancer driver genes, as major network nodes. A mass spectrometry based independent analysis of circulating immunoglobulin (Ig)-bound proteins in ovarian cancer and of ovarian cancer cell surface MHC-II bound peptides also revealed a TP53-MYC related network of antigens. Our findings support the occurrence of a humoral immune response to antigens linked to ovarian cancer driver genes that may have utility for early detection applications.

引用

页数：16

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