Loss of Mitochondrial SDHB Expression: What is its Role in Diffuse Thyroid Lipomatosis?

被引：10

作者：

Lau, E. ^{[1
]}

Freitas, P. ^{[1
]}

Costa, J. ^{[2
]}

Batista, R. ^{[3
]}

Maximo, V. ^{[3
,4
]}

Coelho, R. ^{[3
]}

Matos-Lima, L. ^{[5
]}

Eloy, C. ^{[2
,3
]}

Carvalho, D. ^{[1
]}

机构：

[1] Univ Porto, Fac Med, CHSJ, Dept Endocrinol Diabet & Metab, P-4200319 Oporto, Portugal

[2] Univ Porto, Fac Med, CHSJ, Dept Pathol, P-4200319 Oporto, Portugal

[3] Univ Porto, Fac Med, Inst Mol Pathol & Immunol Univ Porto IPATIMUP, P-4200319 Oporto, Portugal

[4] Univ Porto, Fac Med, Dept Pathol & Oncol, P-4200319 Oporto, Portugal

[5] Univ Porto, Fac Med, Dept Gen Surg, CHSJ, P-4200319 Oporto, Portugal

来源：

HORMONE AND METABOLIC RESEARCH | 2015年 / 47卷 / 03期

关键词：

lipomatosis; mitochondrial dysfunction; adipocyte;

D O I：

10.1055/s-0034-1398559

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diffuse lipomatosis of the thyroid gland is a very rare disease, characterized by extensive infiltration of thyroid parenchyma by mature adipose tissue, usually not accompanied by amyloid fibrils deposition. The pathophysiology of adipose tissue infiltration in the thyroid gland remains unknown. We report a clinical case of a diffuse thyroid lipomatosis, whose immunohistochemical study of succinate dehydrogenase subunit B (SDHB) revealed loss of expression of this protein in the follicular or adipose cells. We detected the presence of a recently described SDHB gene large deletion. Loss of mitochondrial SDHB expression may have a key role in understanding the pathophysiology of thyrolipomatosis, by regulating status of lipid metabolism.

引用

页码：165 / 167

页数：3

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