Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones

被引：209

作者：

Kumar, Krishnan Suresh ^{[1
]}

Ganguly, Swastika ^{[2
]}

Veerasamy, Ravichandran

De Clercq, Erik ^{[3
]}

机构：

[1] KMCH Coll Pharm, Med Chem Res Lab, Coimbatore, Tamil Nadu, India

[2] Birla Inst Technol, Depamnent Pharmaceut Sci, Med Chem Res Lab, Ranchi, Bihar, India

[3] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 11期

关键词：

Quinazoline; Schiff bases; 3-(Benzylideneamino)-2-phenylquinazoline-4(3H)-ones; Non-nucleoside antiviral agents; HSV; FIPV; Influenza; Vaccinia virus; Vesicular stomatitis virus; ANTIMICROBIAL ACTIVITY;

D O I：

10.1016/j.ejmech.2010.07.058

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus. Crown Copyright (C) 2010 Published by Elsevier Masson SAS. All rights reserved.

引用

页码：5474 / 5479

页数：6

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