Bioinspired applications of functional dendrimers

被引：16

作者：

Jang, WD ^{[1
]}

Kataoka, K ^{[1
]}

机构：

[1] Univ Tokyo, Dept Mat Sci & Engn, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2005年 / 15卷 / 01期

关键词：

dendrimer; drug delivery system; biomimetics; therapy; diagnostic;

D O I：

10.1016/S1773-2247(05)50003-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dendrimers are well-controlled monodisperse macromolecules with a regular branching repeating unit from the focal core. Well-predictable three-dimensional architectures of dendrimers closely resemble naturally occurring polymeric systems. During the past two decades the research field of dendrimer chemistry has rapidly expanded. Based on the rapid advances in this area, practical applications of dendrimers have been requested and have attracted increasing attention. The structural precision of dendrimers has motivated numerous studies aimed at bioinspired applications because of the versatility of modifications and the well-defined structural characteristics of dendrimers. Bioinspired applications include use as drug and gene delivery vehicles, protein mimics, anticancer or antiviral agents, vaccines and biomedical diagnostic reagents. The present review article contains the recent progress in bioinspired application of dendrimers.

引用

页码：19 / 30

页数：12

共 124 条

[71] Light-harvesting ionic dendrimer porphyrins as new photosensitizers for photodynamic therapy [J].

Nishiyama, N ;

Stapert, HR ;

Zhang, GD ;

Takasu, D ;

Jiang, DL ;

Nagano, T ;

Aida, T ;

Kataoka, K .

BIOCONJUGATE CHEMISTRY, 2003, 14 (01) :58-66

[72] In vitro gene Transfection using dendritic poly(L-lysine) [J].

Ohsaki, M ;

Okuda, T ;

Wada, A ;

Hirayama, T ;

Niidome, T ;

Aoyagi, H .

BIOCONJUGATE CHEMISTRY, 2002, 13 (03) :510-517

[73] Time-dependent complex formation of dendritic poly(L-lysine) with plasmid DNA and correlation with in vitro transfection efficiencies [J].

Okuda, T ;

Kidoaki, S ;

Ohsaki, M ;

Koyama, Y ;

Yoshikawa, K ;

Niidome, T ;

Aoyagi, H .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2003, 1 (08) :1270-1273

[74] Dendrimer enhanced immunosensors for biological detection [J].

Ong, KK ;

Jenkins, AL ;

Cheng, R ;

Tomalia, DA ;

Durst, HD ;

Jensen, JL ;

Emanuel, PA ;

Swim, CR ;

Yin, R .

ANALYTICA CHIMICA ACTA, 2001, 444 (01) :143-148

[75]

Pistolis G, 1999, CHEM-EUR J, V5, P1440, DOI 10.1002/(SICI)1521-3765(19990503)5:5<1440::AID-CHEM1440>3.3.CO

[76]

2-D

[77] Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery [J].

Plank, C ;

Mechtler, K ;

Szoka, FC ;

Wagner, E .

HUMAN GENE THERAPY, 1996, 7 (12) :1437-1446

[78] Optically active BINOL core-based phenyleneethynylene dendrimers for the enantioselective fluorescent recognition of amino alcohols [J].

Pugh, VJ ;

Hu, QS ;

Zuo, XB ;

Lewis, FD ;

Pu, L .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (18) :6136-6140

[79] Synthesis of boron-rich lysine dendrimers as protein labels in electron microscopy [J].

Qualmann, B ;

Kessels, MM ;

Musiol, HJ ;

Sierralta, WD ;

Jungblut, PW ;

Moroder, L .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (08) :909-911

[80] SYNTHESIS OF PEPTIDE DENDRIMER [J].

RAO, C ;

TAM, JP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (15) :6975-6976

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