Synthesis and function of phospholipids in Staphylococcus aureus

被引：73
作者：
Kuhn, Sebastian [1 ]
Slavetinsky, Christoph J. [1 ]
Peschel, Andreas [1 ]
机构：
[1] Univ Tubingen, Interfac Inst Microbiol & Infect Med, Cellular & Mol Microbiol Div, D-72076 Tubingen, Germany
来源：
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2015年 / 305卷 / 02期
关键词：
Staphylococcus aureus; Membrane; Phospholipids; Phosphatidylglycerol; Lysyl-phosphatidylglycerol; Cardiolipin; LIPOTEICHOIC ACID SYNTHESIS; GRAM-POSITIVE PATHOGENS; VRAFG ABC TRANSPORTER; LYSYL-PHOSPHATIDYLGLYCEROL; ANTIMICROBIAL PEPTIDES; ANTIBIOTIC DAPTOMYCIN; 2-COMPONENT SYSTEM; LIPID HOMEOSTASIS; HUMAN NEUTROPHILS; MEMBRANE;
D O I：
10.1016/j.ijmm.2014.12.016
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Phospholipids are the major components of bacterial membranes, and changes in phospholipid composition affect important cellular processes such as metabolism, stress response, antimicrobial resistance, and virulence. The most prominent phospholipids in Staphylococcus aureus are phosphatidylglycerol, lysylphosphatidylglycerol, and cardiolipin, whose biosynthesis is mediated by a complex protein machinery. Phospholipid composition of the staphylococcal membrane has to be continuously adjusted to changing external conditions, which is achieved by a series of transcriptional and biochemical regulatory mechanisms. This mini-review outlines the current state of knowledge concerning synthesis, regulation, and function of the major staphylococcal phospholipids. (C) 2015 Elsevier GmbH. All rights reserved.
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收藏
页码：196 / 202
页数：7
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