A 64-Channel Readout ASIC for Nanowire Biosensor Array with Electrical Calibration Scheme

被引：3

作者：

Chai, Kevin T. C. ^{[1
]}

Choe, Kunil ^{[1
]}

Bernal, Olivier D. ^{[1
]}

Gopalakrishnan, Pradeep K. ^{[1
]}

Zhang, Guo-Jun ^{[2
]}

Kang, Tae Goo ^{[2
]}

Je, Minkyu ^{[1
]}

机构：

[1] ASTAR, Integrated Circuits & Syst Lab, Inst Microelect, Singapore, Singapore

[2] ASTAR, Inst Microelect, Bioelect Programme, Singapore, Singapore

来源：

2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2010年

关键词：

SILICON NANOWIRE;

D O I：

10.1109/IEMBS.2010.5627783

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A 1.8-mW, 18.5-mm(2) 64-channel current readout ASIC was implemented in 0.18-mu m CMOS together with a new calibration scheme for silicon nanowire biosensor arrays. The ASIC consists of 64 channels of dedicated readout and conditioning circuits which incorporate correlated double sampling scheme to reduce the effect of 1/f noise and offset from the analog front-end. The ASIC provides a 10-bit digital output with a sampling rate of 300 S/s whilst achieving a minimum resolution of 7 pA(rms). A new electrical calibration method was introduced to mitigate the issue of large variations in the nano-scale sensor device parameters and optimize the sensor sensitivity. The experimental results show that the proposed calibration technique improved the sensitivity by 2 to 10 times and reduced the variation between dataset by 9 times.

引用

页码：3491 / 3494

页数：4

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