Association Between Anxiety and Depression and Gastroesophageal Reflux Disease: Results From a Large Cross-sectional Study

被引:100
作者
Choi, Ji Min [1 ,2 ]
Yang, Jong In [1 ,2 ]
Kang, Seung Joo [1 ,2 ]
Han, Yoo Min [1 ,2 ]
Lee, Jooyoung [1 ,2 ]
Lee, Changhyun [1 ,2 ]
Chung, Su Jin [1 ,2 ]
Yoon, Dae Hyun [3 ]
Park, Boram [1 ,2 ]
Kim, Yong Sung [4 ]
机构
[1] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Internal Med, GFC Bldg 152, Seoul 06236, South Korea
[2] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Inst Healthcare Res, GFC Bldg 152, Seoul 06236, South Korea
[3] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Psychiat, Seoul, South Korea
[4] Wonkwang Univ, Sanbon Hosp, Dept Internal Med, Div Gastroenterol, Gunpo, Gyeonggi Do, South Korea
关键词
Anxiety; Depression; Gastroesophageal reflux; Psychology; ASYMPTOMATIC EROSIVE ESOPHAGITIS; QUALITY-OF-LIFE; RISK-FACTORS; PREVALENCE; SYMPTOMS; DISORDERS; INVENTORY; STRESS; HEALTH; CLASSIFICATION;
D O I
10.5056/jnm18069
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims The different clinical manifestations of gastroesophageal reflux disease (GERD) may be influenced by associated psychological factors. We evaluated the psychological status (anxiety and depression) according to each subtype of GERD. Methods Subjects who underwent esophagogastroduodenoscopy and completed a symptom questionnaire between January 2008 and December 2011 were analyzed. The subjects were classified into the following groups: erosive reflux disease (ERD), non-erosive reflux disease (NERD), asymptomatic erosive esophagitis (AEE), and controls. Anxiety and depression were assessed using the State-Trait Anxiety Inventory and Beck Depression Inventory, respectively. Results We analyzed 19 099 subjects: 16 157 (84.6%), 176 (0.9%), 1398 (7.3%), and 1368 (7.2%) in the control, ERD, NERD, and AEE groups, respectively. Multiple multinomial logistic regression revealed a significant association of increased state (adjusted OR, 1.89; 95% CI, 1.53-2.33) and trait anxiety (adjusted OR, 1.78; 95% CI, 1.34-2.35) and depression (adjusted OR, 2.21; 95% CI, 1.75-2.80) with NERD. ERD group showed a significant association only with state anxiety (adjusted OR, 2.20; 95% CI, 1.27-3.81) and depression (adjusted OR, 2.23; 95% CI, 1.18-4.22). The AEE group, however, did not show any significant association with psychological factors. Conclusion This cross-sectional study revealed that anxiety and depression levels were significantly higher in subjects with GERD (notably in the NERD) than in controls.
引用
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页码:593 / 602
页数:10
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