High-Throughput Multi-Product Liquid Chromatography for the Characterization of Monoclonal Antibodies

被引：1

作者：

Rea, Jennifer C. ^{[1
]}

Moreno, G. Tony ^{[1
]}

Lou, Yun ^{[1
]}

Parikh, Rahul ^{[1
]}

Farnan, Dell ^{[1
]}

机构：

[1] Genentech Inc, Prot Analyt Chem, San Francisco, CA 94080 USA

来源：

BIOPHARM INTERNATIONAL | 2010年 / 23卷 / 11期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Monoclonal antibodies represent a significant portion of sales in the biopharmaceuticals market Ever-growing biotechnologypipelines have greatly increased demand for higher throughput, multi-product protein characterization methods By taking a holistic approach to improving the analytical process, one can identify strategies to increase throughput and reduce development times and the costs of analytical methods This article discusses recent advances in high-throughput and multi-product liquid chromatography and electrophoretic methods for protein characterization In addition to advances in analytical methodology, technological advancements in sample preparation throughput and data handling automation add value and time savings to the overall characterization process, which will enable increased productivity and faster product development

引用

页码：44 / +

页数：8

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