Nardostachys chinensis glycoside induces characteristics of neuronal differentiation in rat pheochromocytoma PC12 cells

被引：6
|
作者：
Liu, JH [1 ]
Yin, F [1 ]
Zheng, XX [1 ]
机构：
[1] Chongqing Technol & Business Univ, Nat Med Res Ctr, Chongqing 400067, Peoples R China
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2005年 / 28卷 / 04期
关键词：
Nardostachys chinensis glycoside; acetylcholinesterase; mitogen-activated protein kinase; neurite;
D O I：
10.1248/bpb.28.768
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Rat pheochromocytoma PC12 cells undergo neuronal differentiation in response to nerve growth factor. We show here that exposure of PC12 cells to Nardostachys chinensis glycoside induces the outgrowth of neurites, increases the activity of AChE, triggers cell cycle arrest in G1 and enhances the expression of growth associated protein 43 (GAP-43). Both the outgrowth of neurites and the increase in AChE activity are prevented partly by PD98059, a specific inhibitor of MEK1. These results suggest that N. chinensis glycoside induces the characteristics of neuronal differentiation in PC12 cells via the mitogen-activated protein kinase (MAPK)-related signal cascade.
引用
收藏
页码：768 / 771
页数：4
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