Biomimetic immunomodulation strategies for effective tissue repair and restoration

被引：69

作者：

Villarreal-Leal, Ramiro Alejandro ^{[1
,2
]}

Healey, Gareth David ^{[3
]}

Corradetti, Bruna ^{[1
,3
,4
]}

机构：

[1] Houston Methodist Res Inst, Dept Nanomed, 6670 Bertner Ave, Houston, TX 77030 USA

[2] Tecnol Monterrey, Escuela Med & Ciencias Salud, Ave Morones Prieto 3000, Monterrey 64710, Nuevo Leon, Mexico

[3] Swansea Univ, Inst Life Sci, Med Sch, Singleton Pk, Swansea SA2 8PP, W Glam, Wales

[4] Texas A&M Hlth Sci Ctr, Coll Med, 8441 Riverside Pkwy, Bryan, TX 77807 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2021年 / 179卷

基金：

欧盟地平线“2020”;

关键词：

Immunomodulation; Wound healing; Growth factors; Biomimetic materials; Exosomes; Exosome mimetics; Regeneration; Tissue engineering; Cytokines; Immune system; Functional regeneration; Macrophages; M1; macrophages; M2; Immune response; MESENCHYMAL STEM-CELLS; NF-KAPPA-B; EXTRACELLULAR-MATRIX; MACROPHAGE POLARIZATION; BIOLOGICAL RESPONSES; WOUND REPAIR; SCAFFOLDS; INFLAMMATION; FUSION; REGENERATION;

D O I：

10.1016/j.addr.2021.113913

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inflammation plays a central role in wound healing following injury or disease and is mediated by a precise cascade of cellular and molecular events. Unresolved inflammatory processes lead to chronic inflammation and fibrosis, which can result in prolonged wound healing lasting months or years that hampers tissue function. Therapeutic interventions mediated by immunomodulatory drugs, cells, or biomaterials, are therefore most effective during the inflammatory phase of wound healing when a pro-regenerative environment is essential. In this review, we discuss the advantages of exploiting knowledge of the native tissue microenvironment to develop therapeutics capable of modulating the immune response and promoting functional tissue repair. In particular, we provide examples of the most recent biomimetic platforms proposed to accomplish this goal, with an emphasis on those able to induce macrophage polarization towards a pro-regenerative phenotype. (C) 2021 Elsevier B.V. All rights reserved.

引用

页数：17

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