Self-Assembling Pathway of HiApp Fibrils within Lipid Bilayers

被引：36
作者：
Scalisi, Silvia [1 ]
Sciacca, Michele F. M. [1 ]
Zhavnerko, Genady [2 ]
Grasso, Domenico M. [1 ]
Marletta, Giovanni [1 ]
La Rosa, Carmelo [1 ]
机构：
[1] Univ Catania, Dept Chem Sci, I-95125 Catania, Italy
[2] Belarus Natl Acad Sci, Inst Chem New Mat, Minsk 220141, BELARUS
来源：
CHEMBIOCHEM | 2010年 / 11卷 / 13期
关键词：
diabetes mellitus; fibrils; fluorescence spectroscopy; lipids; membranes; ISLET AMYLOID POLYPEPTIDE; MEMBRANE INTERACTION; AMYLIN; PEPTIDE; IAPP; MECHANISM; PATHOGENESIS; INSULIN; GROWTH;
D O I：
10.1002/cbic.201000090
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(Graph Presented) A combination of atomic force microscopy, quartz crystal microbalance and fluorescence spectroscopy shed light on the mechanism of interaction of hIAPP with zwitterionic model membranes, and allowed us to speculate the toxic behaviour of hIAPP in diabetes mellitus type II. The results suggest that damage of zwitterionic lipid bilayers and fibrillogenesis are two different phenomena. © 2010 Wiley-VCH Verlag GmbH& Co. KGaA, Weinheim.
引用
收藏
页码：1856 / 1859
页数：4
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