Intermuscular fat density as a novel prognostic factor in breast cancer patients treated with adjuvant chemotherapy

被引：9

作者：

Jeon, Ye Won ^{[1
]}

Park, Hyung Soon ^{[2
,3
]}

Ko, Yousun ^{[4
]}

Sung, Yu Sub ^{[5
,6
]}

Shim, Byoung Yong ^{[2
]}

Suh, Young Jin ^{[1
]}

Kim, Hyun A. ^{[7
]}

机构：

[1] Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Surg, Seoul, South Korea

[2] Catholic Univ Korea, St Vincents Hosp, Coll Med, Div Med Oncol,Dept Internal Med, Seoul, South Korea

[3] Catholic Univ Korea, Coll Med, Cell Death Dis Res Ctr, Seoul, South Korea

[4] Asan Med Ctr, Biomed Res Ctr, Asan Inst Life Sci, Seoul, South Korea

[5] Asan Med Ctr, Clin Res Ctr, Seoul, South Korea

[6] Univ Ulsan, Dept Convergence Med, Coll Med, Seoul, South Korea

[7] Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Radiol, 93 Jungbu Daero, Suwon 16247, Gyenggi Do, South Korea

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2021年 / 189卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Breast cancer; Chemotherapy; Fat density; Visceral obesity; Survival; SKELETAL-MUSCLE DEPLETION; BODY-MASS INDEX; NEOADJUVANT CHEMOTHERAPY; COMPUTED-TOMOGRAPHY; SURVIVAL; MORTALITY; IMPACT; WOMEN; AGE;

D O I：

10.1007/s10549-021-06322-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Body composition, including sarcopenia and fat parameters, has received much attention as a prognostic factor in breast cancer. Methods A total of 479 breast cancer patients who underwent surgery and received adjuvant chemotherapy were enrolled in this study. Body composition, including the index and density of skeletal muscle, visceral fat, subcutaneous fat, and intermuscular fat calculated by CT scan, was used as a prognostic factor. The endpoints were breast cancer-specific survival (BCSS) and overall survival (OS). Results The number of patients with stages I, II, and III was 146 (30.5%), 237 (49.5%), and 96 (20%), respectively. Sarcopenia and muscle density were not significant prognostic factors for BCSS and OS. A high visceral fat index (VFI) was an independent prognostic factor for BCSS (HR, 2.55; 95% CI 1.10-5.95, p = 0.03) and OS (HR 2.55, 95% CI 1.26-5.16, p = 0.01). In addition, high intermuscular fat density (IMFD) was also a significant prognostic factor for BCSS (HR, 2.95; 95% CI 1.34-6.46, p = 0.007) and OS (HR 2.28, 95% CI 1.22-4.26, p = 0.01) in multivariate analysis. Conclusion VFI and IMFD were significant prognostic factors for BCSS and OS in breast cancer patients treated with adjuvant chemotherapy.

引用

页码：759 / 768

页数：10

共 35 条

[1] Intermuscular Fat: A Review of the Consequences and Causes [J].