Structural insight into the antibiotic action of telithromycin against resistant mutants

被引：140

作者：

Berisio, R

Harms, J

Schluenzen, F

Zarivach, R

Hansen, HAS

Fucini, P

Yonath, A ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Struct, IL-76100 Rehovot, Israel

[2] Max Planck Inst Mol Genet, Berlin, Germany

[3] Max Planck Res Unit Ribosomal Struct, Hamburg, Germany

[4] CNR, Inst Biostruct & Bioimaging, Naples, Italy

来源：

JOURNAL OF BACTERIOLOGY | 2003年 / 185卷 / 14期

关键词：

D O I：

10.1128/JB.185.14.4276-4279.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.

引用

收藏

页码：4276 / 4279

页数：4

相关论文

共 19 条

[1] Methods used in the structure determination of bovine mitochondrial F-1 ATPase [J].

Abrahams, JP ;

Leslie, AGW .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1996, 52 :30-42

[2] THE CCP4 SUITE - PROGRAMS FOR PROTEIN CRYSTALLOGRAPHY [J].

BAILEY, S .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 :760-763

[3] Structural insight into the role of the ribosomal tunnel in cellular regulation [J].

Berisio, R ;

Schluenzen, F ;

Harms, J ;

Bashan, A ;

Auerbach, T ;

Baram, D ;

Yonath, A .

NATURE STRUCTURAL BIOLOGY, 2003, 10 (05) :366-370

[4] Crystallography & NMR system:: A new software suite for macromolecular structure determination [J].

Brunger, AT ;

Adams, PD ;

Clore, GM ;

DeLano, WL ;

Gros, P ;

Grosse-Kunstleve, RW ;

Jiang, JS ;

Kuszewski, J ;

Nilges, M ;

Pannu, NS ;

Read, RJ ;

Rice, LM ;

Simonson, T ;

Warren, GL .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1998, 54 :905-921

[5] Ribbons [J].

Carson, M .

MACROMOLECULAR CRYSTALLOGRAPHY, PT B, 1997, 277 :493-505

[6] Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA [J].

Douthwaite, S ;

Hansen, LH ;

Mauvais, P .

MOLECULAR MICROBIOLOGY, 2000, 36 (01) :183-192

[7] ROLE OF PROTONATED AND NEUTRAL FORMS OF MACROLIDES IN BINDING TO RIBOSOMES FROM GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA [J].

GOLDMAN, RC ;

FESIK, SW ;

DORAN, CC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (03) :426-431

[8] High resolution structure of the large ribosomal subunit from a mesophilic Eubacterium [J].

Harms, J ;

Schluenzen, F ;

Zarivach, R ;

Bashan, A ;

Gat, S ;

Agmon, I ;

Bartels, H ;

Franceschi, F ;

Yonath, A .

CELL, 2001, 107 (05) :679-688

[9] IMPROVED METHODS FOR BUILDING PROTEIN MODELS IN ELECTRON-DENSITY MAPS AND THE LOCATION OF ERRORS IN THESE MODELS [J].

JONES, TA ;

ZOU, JY ;

COWAN, SW ;

KJELDGAARD, M .

ACTA CRYSTALLOGRAPHICA SECTION A, 1991, 47 :110-119

[10] Activity of the ketolide telithromycin is refractory to erm monomethylation of bacterial rRNA [J].

Liu, MF ;

Douthwaite, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) :1629-1633