Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism

被引:46
作者
Campioli, Enrico [1 ,2 ]
Lee, Sunghoon [1 ,3 ]
Lau, Matthew [1 ,4 ]
Marques, Lucas [1 ,4 ]
Papadopoulos, Vassilios [1 ,2 ,3 ,4 ,5 ]
机构
[1] McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ, Canada
[2] McGill Univ, Dept Med, Montreal, PQ, Canada
[3] McGill Univ, Dept Biochem, Montreal, PQ, Canada
[4] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada
[5] Univ Southern Calif, Dept Pharmacol & Pharmaceut Sci, Sch Pharm, Los Angeles, CA 90007 USA
来源
SCIENTIFIC REPORTS | 2017年 / 7卷
基金
加拿大健康研究院;
关键词
VASCULAR FRACTION DIFFERENTIATION; ACID DIISONONYL ESTER; STEM LEYDIG-CELLS; TESTOSTERONE PRODUCTION; SPRAGUE-DAWLEY; ADIPOSE-TISSUE; ISONONYL ESTER; SHORT-TERM; PHTHALATE; MACROPHAGES;
D O I
10.1038/s41598-017-11325-7
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In 2002, the plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) was introduced in the European market as a substitute for endocrine-disrupting phthalates. We found that in utero exposure of rats to DINCH from gestational day 14 until parturition affected reproductive organ physiology and reduced circulating testosterone levels at post-natal day 60, indicating a long-term effect on Leydig cells of the testis. Metabolically, animals exhibited randomly increased serum glucose concentrations not associated with impaired glucose utilization. Analysis of liver markers in the serum showed a hepatic effect; e.g. reduced bilirubin levels and albumin/globulin ratio. At post-natal day 200, random appearance of testicular atrophy was noted in exposed offspring, and limited changes in other reproductive parameters were observed. In conclusion, DINCH exposure appears to directly affect Leydig cell function, likely causing premature aging of the testes and impaired liver metabolic capacity. These effects might be attenuated with physiologic aging.
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页数:14
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