The analysis of allodynia in patients with idiopathic intracranial hypertension

被引:41
作者
Ekizoglu, Esme [1 ]
Baykan, Betul [1 ]
Orhan, Elif K. [1 ]
Ertas, Mustafa [1 ]
机构
[1] Istanbul Univ, Dept Neurol, Istanbul Fac Med, TR-34390 Istanbul, Turkey
关键词
Idiopathic intracranial hypertension; allodynia; central sensitization; headache; secondary headache; TENSION-TYPE HEADACHE; CUTANEOUS ALLODYNIA; CENTRAL SENSITIZATION; BRUSH ALLODYNIA; MIGRAINE; PAIN; ASSOCIATION; ACTIVATION; NEURONS;
D O I
10.1177/0333102412457091
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives: Allodynia is frequently associated with migraine and other primary headaches. Our aim was to investigate the presence of allodynia and related features in idiopathic intracranial hypertension (IIH), which is a disabling secondary headache disorder. Methods: We included 46 IIH patients and analyzed their clinical and laboratory findings retrospectively. Allodynia was assessed using the validated 12-item allodynia symptom checklist (ASC-12), in addition to examining pressure (with von Frey filaments) and brush allodynia. Results: Allodynia was detected in 23 (50%) of IIH patients with ASC-12 and/or instrumental testing. The most commonly reported location was unilateral V1 distribution. The allodynic symptom profile was similar but milder when compared to 143 migraineurs with ASC-12. Only the aggravation of headache with physical activity emerged as a significant variable associated with allodynia in IIH. Among allodynic patients, only eight had previous migraine diagnosis. After onset of IIH, 20 patients reported migraine-like headache, while only three reported non-migrainous headache. In contrast, 13 of 23 non-allodynic IIH patients had non-migrainous headache features (p = 0.0045). Conclusion: Half of the IIH patients reported allodynia, and these allodynic patients had mostly migraine-like headache profiles. Our study suggested that IIH may trigger some common mechanisms with migraine in pain pathways causing allodynia.
引用
收藏
页码:1049 / 1058
页数:10
相关论文
共 39 条
[1]   Headache characteristics and chronification of migraine and tension-type headache: A population-based study [J].
Ashina, Sait ;
Lyngberg, Ann ;
Jensen, Rigmor .
CEPHALALGIA, 2010, 30 (08) :943-952
[2]   Identifying cutaneous allodynia in chronic migraine using a practical clinical method [J].
Ashkenazi, A. ;
Sholtzow, M. ;
Shaw, J. W. ;
Burstein, R. ;
Young, W. B. .
CEPHALALGIA, 2007, 27 (02) :111-117
[3]   The effects of greater occipital nerve block and trigger point injection on brush allodynia and pain in migraine [J].
Ashkenazi, A ;
Young, WB .
HEADACHE, 2005, 45 (04) :350-354
[4]   Dynamic mechanical (brush) allodynia in cluster headache [J].
Ashkenazi, A ;
Young, WB .
HEADACHE, 2004, 44 (10) :1010-1012
[6]   Prevalence and characteristics of allodynia in headache sufferers - A population study [J].
Bigal, M. E. ;
Ashina, S. ;
Burstein, R. ;
Reed, M. L. ;
Buse, D. ;
Serrano, D. ;
Lipton, R. B. .
NEUROLOGY, 2008, 70 (17) :1525-1533
[7]  
Burstein R, 2000, ANN NEUROL, V47, P614, DOI 10.1002/1531-8249(200005)47:5<614::AID-ANA9>3.0.CO
[8]  
2-N
[9]   Tbe development of cutaneous allodynia during a migraine attack - Clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine [J].
Burstein, R ;
Cutrer, MF ;
Yarnitsky, D .
BRAIN, 2000, 123 :1703-1709
[10]  
Burstein Rami, 2010, Handb Clin Neurol, V97, P207, DOI 10.1016/S0072-9752(10)97016-4