Age-, sex- and disease subtypeerelated foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis

被引：11

作者：

Karalexi, Maria A. ^{[1
]}

Dessypris, Nick ^{[1
]}

Ma, Xiaomei ^{[2
]}

Spector, Logan G. ^{[3
]}

Marcotte, Erin ^{[3
]}

Clavel, Jacqueline ^{[4
,5
]}

Pombo-de-Oliveira, Maria S. ^{[6
]}

Heck, Julia E. ^{[7
]}

Roman, Eve ^{[8
]}

Mueller, Beth A. ^{[9
,10
]}

Hansen, Johnni ^{[11
]}

Auvinen, Anssi ^{[12
]}

Lee, Pei-Chen ^{[13
]}

Schuz, Joachim ^{[14
]}

Magnani, Corrado ^{[15
,16
]}

Mora, Ana M. ^{[17
]}

Dockerty, John D. ^{[18
]}

Scheurer, Michael E. ^{[19
]}

Wang, Rong ^{[2
]}

Bonaventure, Audrey ^{[4
]}

Kane, Eleanor ^{[8
]}

Doody, David R. ^{[9
]}

Erdmann, Friederike ^{[14
,20
]}

Kang, Alice Y. ^{[21
]}

Metayer, Catherine ^{[21
]}

Milne, Elizabeth ^{[22
]}

Petridou, Eleni Th ^{[1
,23
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Dept Hyg Epidemiol & Med Stat, Med Sch, 75 Mikras Asias Str, Athens 11527, Greece

[2] Yale Sch Med, Yale Sch Publ Hlth Canc Prevent & Control, Yale Comprehens Canc Ctr, Dept Chron Dis Epidemiol, New Haven, CT USA

[3] Univ Minnesota, Dept Pediat, Div Epidemiol & Clin Res, Minneapolis, MN 55455 USA

[4] Paris Descartes Univ, INSERM, CRESS, UMR S1153, Villejuif, France

[5] CHU Nancy, Hop Paul Brousse, AP HP, Natl Registry Childhood Canc, Nancy, France

[6] Inst Nacl Canc, Pediat Hematol Oncol Program, Rio De Janeiro, Brazil

[7] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA

[8] Univ York, Dept Hlth Sci, Epidemiol & Canc Stat Grp, York, N Yorkshire, England

[9] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA

[10] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA

[11] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[12] Univ Tampere, Fac Social Sci, Tampere, Finland

[13] Natl Taipei Univ Nursing & Hlth Sci, Dept Hlth Care Management, Taipei, Taiwan

[14] Int Agcy Res Canc IARC, Sect Environm & Radiat, Lyon, France

[15] CPO Piedmont, Canc Epidemiol Unit, Dept Translat Med, Novara, Italy

[16] Univ Piemonte Orientale, Novara, Italy

[17] Univ Nacl, Cent Amer Inst Studies Tox Subst IRET, Heredia, Costa Rica

[18] Univ Otago, Dunedin Sch Med, Dept Preventat & Social Med, Dunedin, New Zealand

[19] Texas Childrens Canc Ctr, Baylor Coll Med, Dept Pediat, Houston, TX USA

[20] Danish Canc Soc Res Ctr, Childhood Canc Res Grp, Copenhagen, Denmark

[21] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

[22] Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Perth, WA, Australia

[23] Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF CANCER | 2020年 / 130卷

基金：

巴西圣保罗研究基金会;

关键词：

Foetal growth; Birthweight for gestational age; Birth length; Weight-for-length ratio; Acute myeloid leukaemia; Childhood; DNA TOPOISOMERASE-II; BIRTH-WEIGHT; GESTATIONAL-AGE; MATERNAL OBESITY; INFANT LEUKEMIA; UNITED-STATES; FUSION GENES; CORD BLOOD; METAANALYSIS; CANCER;

D O I：

10.1016/j.ejca.2020.01.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: Evidence for an association of foetal growth with acute myeloid leukaemia (AML) is inconclusive. AML is a rare childhood cancer, relatively more frequent in girls, with distinct features in infancy. In the context of the Childhood Leukemia International Consortium (CLIC), we examined the hypothesis that the association may vary by age, sex and disease subtype using data from 22 studies and a total of 3564 AML cases. Methods: Pooled estimates by age, sex and overall for harmonised foetal growth markers in association with AML were calculated using the International Fetal and Newborn Growth Consortium for the 21st Century Project for 17 studies contributing individual-level data; meta-analyses were, thereafter, conducted with estimates provided ad hoc by five more studies because of administrative constraints. Subanalyses by AML subtype were also performed. Results: A nearly 50% increased risk was observed among large-for-gestational-age infant boys (odds ratio [OR]: 1.49, 95% confidence interval [CI]: 1.03-2.14), reduced to 34% in boys aged <2 years (OR: 1.34, 95% CI: 1.05-1.71) and 25% in boys aged 0-14 years (OR: 1.25, 95% CI: 1.06-1.46). The association of large for gestational age became stronger in boys with M0/M1subtype (OR: 1.80, 95% CI: 1.15-2.83). Large birth length for gestational age was also positively associated with AML (OR: 1.38, 95% CI: 1.00-1.92) in boys. By contrast, there were null associations in girls, as well as with respect to associations of decelerated foetal growth markers. Conclusions: Accelerated foetal growth was associated with AML, especially in infant boys and those with minimally differentiated leukaemia. Further cytogenetic research would shed light into the underlying mechanisms. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页码：1 / 11

页数：11

共 59 条

[1] Gene Expression in Placentas From Nondiabetic Women Giving Birth to Large for Gestational Age Infants [J].