The relationship between glutathione peroxidase and bioimpedance parameters in nondiabetic hemodialysis patients

被引:7
作者
Celik, Gulperi [1 ]
Yontem, Mustafa [2 ]
Cilo, Mustafa [2 ]
Bilge, Murat [2 ]
Mehmetoglu, Idris [3 ]
Unaldi, Mustafa [3 ]
机构
[1] Selcuk Univ, Div Nephrol, Dept Internal Med, Selcuklu Sch Med, TR-42250 Selcuklu, Konya, Turkey
[2] Dumlupinar Univ, Dept Biol, Art & Sci Fac, Kutahya, Turkey
[3] Selcuk Univ, Dept Biochem, Meram Med Sch, TR-42250 Selcuklu, Konya, Turkey
关键词
Hemodialysis; glutathione peroxidase; malnutrition; body cell mass; intracellular water; CHRONIC-RENAL-FAILURE; OXIDATIVE STRESS MARKERS; BODY-COMPOSITION; MAINTENANCE DIALYSIS; BIOELECTRICAL-IMPEDANCE; HEPATITIS-C; INFLAMMATION; DISEASE; MALNUTRITION; SPECTROSCOPY;
D O I
10.1111/j.1542-4758.2011.00628.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
There is growing evidence from experimental and clinical studies that oxidative stress is involved in the pathogenesis of malnutrition. This cross-sectional study aimed to investigate the relationship between glutathione peroxidase (GPx) levels as a marker of antioxidant status and the nutritional status assessed by bioimpedance analysis (BIA). Ninety-seven nondiabetic stable outpatient uremic adults undergoing chronic hemodialysis (HD) were recruited for this study. Impedance measurements were performed using a multifrequency bioelectrical impedance analyzer after dialysis. GPx levels correlated with intracellular water (ICW) (r?=?0.341, P?=?0.011), ICW/total body weight (r?=?0.320, P?=?0.017), lean body mass (r?=?0.300, P?=?0.026) and total body cell mass (r?=?0.339, P?=?0.011). When patients were divided into two groups according to mean GPx levels (83.9 U/gr hemoglobin), the patients with higher GPx (GPx?>?83.9?U/gr hemoglobin) had higher albumin (P?=?0.038), lean body mass (P?=?0.026), ICW (P?=?0.011), and total body cell mass (P?=?0.011) compared with those with lower GPx (GPx?=?83.9 U/gr hemoglobin). Furthermore, in the patients with higher GPx, body fat; extracellular water/total body water; illness marker and body fat mass index were lower than other group. In conclusion, our results reveal correlation indicating a relationship between antioxidant status (as measured by GPx) and nutritional status as assessed by BIA in nondiabetic HD patients.
引用
收藏
页码:274 / 281
页数:8
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