Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

被引:1137
作者
Jiang, Xianjie [1 ,2 ,3 ,4 ,5 ,6 ]
Wang, Jie [4 ,5 ]
Deng, Xiangying [4 ,5 ]
Xiong, Fang [4 ,5 ]
Ge, Junshang [1 ,2 ,3 ,4 ,5 ]
Xiang, Bo [1 ,2 ,3 ,4 ,5 ,6 ]
Wu, Xu [4 ,5 ,7 ]
Ma, Jian [1 ,2 ,3 ,4 ,5 ,6 ]
Zhou, Ming [1 ,2 ,3 ,4 ,5 ,6 ]
Li, Xiaoling [1 ,2 ,3 ,4 ,5 ,6 ]
Li, Yong [4 ,5 ,8 ]
Li, Guiyuan [1 ,2 ,3 ,4 ,5 ,6 ]
Xiong, Wei [1 ,2 ,3 ,4 ,5 ,6 ]
Guo, Can [1 ,2 ,3 ,4 ,5 ,6 ]
Zeng, Zhaoyang [1 ,2 ,3 ,4 ,5 ,6 ]
机构
[1] Cent S Univ, NHC Key Lab Carcinogenesis, Changsha 410013, Hunan, Peoples R China
[2] Cent S Univ, Hunan Canc Hosp, Hunan Key Lab Translat Radiat Oncol, Changsha 410013, Hunan, Peoples R China
[3] Cent S Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China
[4] Cent S Univ, Chinese Minist Educ, Canc Res Inst, Key Lab Carcinogenesis & Canc Invas, Changsha 410078, Hunan, Peoples R China
[5] Cent S Univ, Sch Basic Med Sci, Changsha 410078, Hunan, Peoples R China
[6] Cent S Univ, Xiangya Hosp 3, Dis Genome Res Ctr, Hunan Key Lab Nonresolving Inflammat & Canc, Changsha 410013, Hunan, Peoples R China
[7] Univ North Dakota, Dept Chem, Grand Forks, ND 58202 USA
[8] Cleveland Clin, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44195 USA
基金
中国国家自然科学基金;
关键词
Tumor immune escape; PD-L1; PD-1; Tumor microenvironment; Inflammatory factor; HYPOXIA-INDUCIBLE FACTOR; PD-L1; EXPRESSION; IFN-GAMMA; NASOPHARYNGEAL CARCINOMA; B7-H1; NONCODING RNA; CANCER CELLS; T-CELLS; SIGNALING PATHWAYS; DENDRITIC CELLS;
D O I
10.1186/s12943-018-0928-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tumor immune escape is an important strategy of tumor survival. There are many mechanisms of tumor immune escape, including immunosuppression, which has become a research hotspot in recent years. The programmed death ligand-1/programmed death-1 (PD-L1/PD-1) signaling pathway is an important component of tumor immunosuppression, which can inhibit the activation of T lymphocytes and enhance the immune tolerance of tumor cells, thereby achieving tumor immune escape. Therefore, targeting the PD-L1/PD-1 pathway is an attractive strategy for cancer treatment; however, the therapeutic effectiveness of PD-L1/PD-1 remains poor. This situation requires gaining a deeper understanding of the complex and varied molecular mechanisms and factors driving the expression and activation of the PD-L1/PD-1 signaling pathway. In this review, we summarize the regulation mechanisms of the PD-L1/PD-1 signaling pathway in the tumor microenvironment and their roles in mediating tumor escape. Overall, the evidence accumulated to date suggests that induction of PD-L1 by inflammatory factors in the tumor microenvironment may be one of the most important factors affecting the therapeutic efficiency of PD-L1/PD-1 blocking.
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页数:17
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