Development of Safe One-Pot Synthesis of N-1-and C-2-Substituted Benzimidazole via Reductive Cyclization of o-Nitroarylamine Using Na2S2O4

被引：28

作者：

Oda, Shinichi ^{[1
]}

Shimizu, Hideki ^{[1
]}

Aoyama, Yasunori ^{[1
]}

Ueki, Tatsuo ^{[1
]}

Shimizu, Sumio ^{[1
]}

Osato, Hiroshi ^{[1
]}

Takeuchi, Yoshiyuki ^{[1
]}

机构：

[1] Shionogi & Co Ltd, Chem Dev Ctr, CMC Dev Labs, Amagasaki, Hyogo 6600813, Japan

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2012年 / 16卷 / 01期

关键词：

NITRO-COMPOUNDS; THERMAL HAZARDS; POLYMERASE; INHIBITORS; NITROANILINES; DERIVATIVES;

D O I：

10.1021/op200251c

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We report that the reductive cyclization of o-nitroarylamine with aldehyde using sodium dithionite (Na2S2O4) could be accelerated by addition of H2O, which made it possible to control the heat release of the reaction by semibatch-type operation. Safety evaluation was performed using DSC, ARSST, in situ IR analysis, and Multimax.

引用

页码：96 / 101

页数：6

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