HCC Risk;
Cancer;
Drug Development;
Epidemiology;
CHRONIC DELTA-HEPATITIS;
AMPHIPATHIC DNA POLYMERS;
D VIRUS-INFECTION;
WESTERN BRAZILIAN AMAZON;
CHRONIC LIVER-DISEASE;
B SURFACE-ANTIGEN;
RISK-FACTORS;
ENDEMIC AREA;
GENOTYPE-II;
HEPATOCELLULAR-CARCINOMA;
D O I:
10.1053/j.gastro.2018.09.058
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
Hepatitis delta virus (HDV) infection of humans was first reported in 1977, and now it is now estimated that 15-20 million people are infected worldwide. Infection with HDV can be an acute or chronic process that occurs only in patients with an hepatitis B virus infection. Chronic HDV infection commonly results in the most rapidly progressive form of viral hepatitis; it is the chronic viral infection that is most likely to lead to cirrhosis, and it is associated with an increased risk of hepatocellular carcinoma. HDV infection is the only chronic human hepatitis virus infection without a therapy approved by the US Food and Drug Administration. Peginterferon alfa is the only recommended therapy, but it produces unsatisfactory results. We review therapeutic agents in development, designed to disrupt the HDV life cycle, that might benefit patients with this devastating disease.
机构:
Baqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, IranBaqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, Iran
Alavian, Seyed Moayed
Kabir, Ali
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Ctr Educ Res Med Sci, Tehran, Iran
Shahid Beheshti Univ Med Sci, Dept Epidemiol, Tehran, IranBaqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, Iran
Kabir, Ali
Hosseini, Seyed Yaser Saiedi
论文数: 0引用数: 0
h-index: 0
机构:
Baqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, IranBaqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, Iran
Hosseini, Seyed Yaser Saiedi
Aalaei-Andabili, Seyed Hossein
论文数: 0引用数: 0
h-index: 0
机构:
Baqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, IranBaqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, Iran
机构:
Baqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, IranBaqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, Iran
Alavian, Seyed Moayed
Kabir, Ali
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Ctr Educ Res Med Sci, Tehran, Iran
Shahid Beheshti Univ Med Sci, Dept Epidemiol, Tehran, IranBaqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, Iran
Kabir, Ali
Hosseini, Seyed Yaser Saiedi
论文数: 0引用数: 0
h-index: 0
机构:
Baqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, IranBaqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, Iran
Hosseini, Seyed Yaser Saiedi
Aalaei-Andabili, Seyed Hossein
论文数: 0引用数: 0
h-index: 0
机构:
Baqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, IranBaqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, Iran