Multiple intracranial tumors in Philadelphia chromosome positive acute lymphoblastic leukemia: Successful treatment following aggressive supportive care, early cranial radiation, high dose chemotherapy and imatinib

被引：9

作者：

Cuvelier, Geoff D. E. ^{[1
]}

Vitali, Aleksander M. ^{[2
,3
]}

Ford, Jason C.

Dix, David B. ^{[1
]}

机构：

[1] British Columbia Childrens Hosp, Div Pediat Hematol Oncol BMT, Vancouver, BC V6H 3V4, Canada

[2] British Columbia Childrens Hosp, Div Pediat Neurosurg, Vancouver, BC V6H 3V4, Canada

[3] British Columbia Childrens Hosp, Div Pediat Hematopathol, Vancouver, BC V6H 3V4, Canada

来源：

PEDIATRIC BLOOD & CANCER | 2008年 / 51卷 / 01期

关键词：

acute lymphoblastic leukaemia; central nervous system; chloroma; granulocytic sarcoma; intracranial tumors; philadelphia chromosome;

D O I：

10.1002/pbc.21562

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the first case of multiple intracranial tumors ("chloromas") at diagnosis of Philadelphia chromosome positive acute lymphoblastic leukemia. The patient presented comatose with signs of cerebral herniation. Initial management of raised intracranial pressure and hyperleukocytosis followed by emergent whole brain radiation therapy reversed the life-threatening neurological signs. High-dose chemotherapy combined with daily imatinib mesylate induced a rapid and sustained bone marrow remission. Ongoing rehabilitation resulted in a near complete neurological recovery within 6 months of diagnosis. This outcome justifies aggressive early management of increased intracranial pressure and hyperleukocytosis in future similar presentations.

引用

页码：135 / 137

页数：3

共 15 条

[1] Clinical significance of central nervous system involvement at diagnosis of pediatric acute myeloid leukemia: a single institution's experience [J].