Solution and solid phase synthesis of 5-alkoxyhydantoin libraries with a three-fold functional diversity

被引：91
作者：
Hanessian, S
Yang, RY
机构：
[1] Department of Chemistry, Université de Montréal, Montreal, Que. H3C 3J7, C.P. 6128, Succ. Centre-ville
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 33期
基金：
加拿大自然科学与工程研究理事会;
关键词：
D O I：
10.1016/0040-4039(96)01244-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general method for the synthesis of 5-alkoxyhydantoins in solution and on solid support is described. A library of fifty discrete 5-alkoxyhydantoins with three functional group variations was prepared. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：5835 / 5838
页数：4
相关论文
共 21 条
[1]   REACTIONS OF UREAS WITH GLYOXYLIC-ACID AND METHYL GLYOXYLATE [J].
BENISHAI, D ;
ALTMAN, J ;
BERNSTEIN, Z .
TETRAHEDRON, 1977, 33 (10) :1191-1196
[2]   Combinatorial organic synthesis using Parke-Davis's DIVERSOMER method [J].
DeWitt, SH ;
Czarnik, AW .
ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) :114-122
[3]   DIVERSOMERS - AN APPROACH TO NONPEPTIDE, NONOLIGOMERIC CHEMICAL DIVERSITY [J].
DEWITT, SH ;
KIELY, JS ;
STANKOVIC, CJ ;
SCHROEDER, MC ;
CODY, DMR ;
PAVIA, MR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :6909-6913
[4]   Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization cleavage step [J].
Dressman, BA ;
Spangle, LA ;
Kaldor, SW .
TETRAHEDRON LETTERS, 1996, 37 (07) :937-940
[5]   AN EFFICIENT SYNTHESIS OF N-HYDROXY-ALPHA-AMINO ACID-DERIVATIVES OF HIGH OPTICAL PURITY [J].
FEENSTRA, RW ;
STOKKINGREEF, EHM ;
NIVARD, RJF ;
OTTENHEIJM, HCJ .
TETRAHEDRON LETTERS, 1987, 28 (11) :1215-1218
[6]   INTERCONVERSION OF (R) AND (S)-ALPHA-HYDROXY ESTERS - PRECURSORS OF (S) AND (R)-O-BENZYL-ALPHA-HYDROXYLAMINO ACID-ESTERS OF HIGH OPTICAL PURITY [J].
FEENSTRA, RW ;
STOKKINGREEF, EHM ;
NIVARD, RJF ;
OTTENHEIJM, HCJ .
TETRAHEDRON, 1988, 44 (17) :5583-5595
[7]  
FELDER ER, 1994, CHIMIA, V48, P531
[8]  
FELDER ER, 1996, ACC CHEM RES, V29
[9]   APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .1. BACKGROUND AND PEPTIDE COMBINATORIAL LIBRARIES [J].
GALLOP, MA ;
BARRETT, RW ;
DOWER, WJ ;
FODOR, SPA ;
GORDON, EM .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (09) :1233-1251
[10]   APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS [J].
GORDON, EM ;
BARRETT, RW ;
DOWER, WJ ;
FODOR, SPA ;
GALLOP, MA .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) :1385-1401
123