Nickel-catalyzed sp2 C-H bonds arylation of N-aromatic heterocycles with Grignard reagents at room temperature

被引：35

作者：

Qu, Gui-Rong ^{[1
]}

Xin, Peng-Yang ^{[1
]}

Niu, Hong-Ying ^{[2
]}

Wang, Dong-Chao ^{[1
]}

Ding, Rui-Fang ^{[1
]}

Guo, Hai-Ming ^{[1
]}

机构：

[1] Henan Normal Univ, Minist Educ, Key Lab Green Chem Media & React, Coll Chem & Environm Sci, Xinxiang 453007, Henan, Peoples R China

[2] Henan Inst Sci & Technol, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 39期

关键词：

CROSS-COUPLING REACTIONS; ORGANIC HALIDES; PALLADIUM; ACTIVATION; FUNCTIONALIZATION; STRAIGHTFORWARD; INDOLES;

D O I：

10.1039/c1cc14558d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel protocol for nickel-catalyzed direct sp(2) C-H bond arylation of purines has been developed. This new reaction proceeded efficiently at room temperature using Grignard reagent as the coupling partner within 5 hours in good to high yields. This approach provides a new access to a variety of C8-arylpurines which are potentially of great importance in medicinal chemistry.

引用

页码：11140 / 11142

页数：3

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