Hairpin Folding Behavior of Mixed α/β-Peptides in Aqueous Solution

被引：44

作者：

Lengyel, George A. ^{[1
]}

Frank, Rebecca C. ^{[1
]}

Horne, W. Seth ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 12期

关键词：

SHEET SECONDARY STRUCTURE; BETA-HAIRPIN; AROMATIC INTERACTIONS; AMINO-ACIDS; FOLDAMERS; HELIX; SEQUENCE; DESIGN; MODEL; STABILITY;

D O I：

10.1021/ja2002346

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The invention of new strategies for the design of protein-mimetic oligomers that manifest the folding encoded in natural amino acid sequences is a significant challenge. In contrast to the a-helix, mimicry of protein beta-sheets is less understood. We report here the aqueous folding behavior of a prototype alpha-peptide hairpin model sequence varied at cross-strand positions by incorporation of 16 different beta-amino acid monomers. Our results provide a folding propensity scale for beta-residues in a protein beta-sheet context as well as high-resolution structures of several mixed-backbone alpha/beta-peptide hairpins in water.

引用

页码：4246 / 4249

页数：4

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