Adiponectin-Secretion-Promoting Phenylethylchromones from the Agarwood of Aquilaria malaccensis

被引：26

作者：

Ahn, Sungjin ^{[1
]}

Chi Thanh Ma ^{[2
]}

Choi, Jung Min ^{[1
]}

An, Seungchan ^{[1
]}

Lee, Moonyoung ^{[1
]}

Thi Hong Van Le ^{[2
]}

Pyo, Jeong Joo ^{[1
]}

Lee, Joochang ^{[1
,4
]}

Choi, Min Sik ^{[3
]}

Kwon, Sung Won ^{[1
]}

Park, Jeong Hill ^{[1
]}

Noh, Minsoo ^{[1
]}

机构：

[1] Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, 1 Gwanak Ro, Seoul 08826, South Korea

[2] Univ Med & Pharm Ho Chi Minh City, Dept Pharmacognosy, Ho Chi Minh City 700000, Vietnam

[3] Dongduk Womens Univ, Coll Pharm, Seoul 02748, South Korea

[4] Carnegie Mellon Univ, Dept Computat Biol, Pittsburgh, PA 15213 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

GAMMA PPAR-GAMMA; 2-(2-PHENYLETHYL)CHROMONE DERIVATIVES; INSULIN-RESISTANCE; CRYSTAL-STRUCTURE; RECEPTOR LIGANDS; PARTIAL AGONIST; CHROMONE; BINDING;

D O I：

10.1021/acs.jnatprod.8b00635

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The therapeutic potential of adiponectin regulation has received interest because of its association with diverse human disease conditions, such as diabetes, obesity, atherosclerosis, and cancer. Phenylethylchromone derivatives from Aquilaria malaccensis-derived agarwood promoted adiponectin secretion during adipogenesis in human bone marrow mesenchymal stem cells, and 5,6-dihydroxy-2-(2-phenylethyl)chromone (1) was identified as a new chromone derivative. A target identification study with the most potent adiponectin-secretion-promoting phenyl-ethylchromones, 6-methoxy-2-(2-phenylethyl)chromone (3) and 7-methoxy-2-(2-phenylethyl) chromone (4), showed that they are PPAR gamma partial agonists. Therefore, the diverse therapeutic effects of agarwood are associated with a PPAR gamma-mediated adiponectin-secretion-promoting mechanism.

引用

页码：259 / 264

页数：6

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