Biogenesis of MiRNA-195 and its role in biogenesis, the cell cycle, and apoptosis

被引：106
作者：
He, Jun-Feng [1 ]
Luo, Yu-Mei [1 ]
Wan, Xin-Hong [1 ]
Jiang, Deqian [2 ]
机构：
[1] Shenzhen Longgang Dist Peoples Hosp, Dept Cardiol, Guang Dong Med Coll, Shenzhen 518172, Peoples R China
[2] Cent S Univ, Dept Cardiol, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China
来源：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2011年 / 25卷 / 06期
关键词：
microRNA-195; biogenesis; cell cycle; apoptosis; SUPPRESSES TUMORIGENICITY; DIFFERENTIAL EXPRESSION; PREFRONTAL CORTEX; MICRORNA; CANCER; SCHIZOPHRENIA; CARCINOMA; PATTERN; GROWTH;
D O I：
10.1002/jbt.20396
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
microRNA-195(miR-195) is an important member of the micro-15/16/195/424/497 family, and which is activated in multiple diseases, such as cancers, heart failure, and schizophrenia. Mir-195 regulates a plethora of target proteins, which are involved in the cell cycle, apoptosis, proliferation. WEE1, CDK6, and Bcl-2 are confirmed target genes of miR-195 that are involved in miR-195-mediated cell-cycle and apoptosis effects. However, the mechanism of miR-195 action is not completely understood. This review summarizes recent the research progress regarding the roles of miR-195 in the cell cycle and in apoptosis. (c) 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:404408 2011; View this article online at . DOI 10.1002/jbt.20396
引用
收藏
页码：404 / 408
页数：5
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