Role of MicroRNAs in the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

被引：9

作者：

Zhang, Cheng ^{[1
]}

Wang, Ping ^{[2
]}

Li, Yongqiang ^{[1
]}

Huang, Changxin ^{[1
]}

Ni, Wei ^{[1
]}

Chen, Yidan ^{[1
]}

Shi, Junping ^{[1
]}

Chen, Gongying ^{[1
]}

Hu, Xiangrong ^{[1
]}

Ye, Meng ^{[2
]}

Duan, Shiwei ^{[2
]}

Wang, Kaifeng ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Affiliated Hosp, Dept Med Oncol, Hangzhou, Zhejiang, Peoples R China

[2] Ningbo Univ, Sch Med, Ningbo, Zhejiang, Peoples R China

来源：

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2019年 / 302卷 / 02期

基金：

中国国家自然科学基金;

关键词：

nonalcoholic fatty liver disease; hepatocellular carcinoma; microRNA; therapy; CIRCULATING MICRORNAS; INSULIN-RESISTANCE; CHOLINE-DEFICIENT; OXIDATIVE STRESS; FEEDBACK LOOP; RISK-FACTORS; NAFLD; ACTIVATION; STEATOHEPATITIS; SUPPRESSES;

D O I：

10.1002/ar.23954

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Hepatocellular carcinoma (HCC) is a prevalent liver malignancy that can be developed from nonalcoholic fatty liver disease (NAFLD). Numerous pathophysiological alterations, including insulin resistance, specific cytokine release, oxidative stress, and mitochondrial damage, are involved in the transition of NAFLD to cirrhosis and HCC. MicroRNAs, as post-transcriptional modulators, play a critical role in the pathogenesis of NAFLD-related HCC by regulating lipid metabolism, glucose homeostasis, cell proliferation, apoptosis, migration, and differentiation. This review summarizes the current progress of microRNAs in the risk and prognosis of NAFLD-related HCC. Anat Rec, 302:193-200, 2019. (c) 2018 Wiley Periodicals, Inc.

引用

页码：193 / 200

页数：8

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