Cerebrolysin Alleviating Effect on Glutamate-Mediated Neuroinflammation Via Glutamate Transporters and Oxidative Stress

被引：19

作者：

Avci, Seydanur ^{[1
]}

Gunaydin, Sukran ^{[2
]}

Ari, Neziha Senem ^{[3
]}

Sulukoglu, Emine Karaca ^{[4
]}

Polat, Ozlem Erol ^{[5
]}

Gecili, Ibrahim ^{[6
]}

Yeni, Yesim ^{[6
]}

Yilmaz, Aysegul ^{[6
]}

Genc, Sidika ^{[7
]}

Hacimuftuoglu, Ahmet ^{[6
]}

Yildirim, Serkan ^{[8
]}

Mokresh, Muhammed Yasser ^{[8
]}

Findik, Damla Gul ^{[9
]}

Tsatsakis, Aristidis ^{[10
]}

Margina, Denisa ^{[11
]}

Tsarouhas, Konstantinos ^{[12
]}

Wallace, David R. ^{[13
]}

Taghizadehghalehjoughi, Ali ^{[7
]}

机构：

[1] Ataturk Univ, Fac Vet Med, TR-25240 Erzurum, Turkey

[2] Ataturk Univ, Fac Sci, Dept Mol Biol & Genet, TR-25240 Erzurum, Turkey

[3] Kutahya Hlth Sci Univ, Dept Histol & Embryol, TR-43000 Kutahya, Turkey

[4] Erzurum Tech Univ, Dept Mol Biol & Genet, TR-25050 Erzurum, Turkey

[5] Ataturk Univ, Fac Vet Med, Dept Physiol, TR-25240 Erzurum, Turkey

[6] Ataturk Univ, Fac Med, Dept Med Pharmacol, TR-25240 Erzurum, Turkey

[7] Bilecik Seyh Edebali Univ, Fac Med, Dept Med Pharmacol, TR-11230 Bilecik, Turkey

[8] Ataturk Univ, Fac Vet Med, Dept Pathol, TR-25240 Erzurum, Turkey

[9] Bilecik Seyh Edebali Univ, Fac Med, Dept Histol & Embryol, TR-11230 Bilecik, Turkey

[10] Univ Crete, Fac Med, Dept Forens Sci & Toxicol, Iraklion 71003, Greece

[11] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, Bucharest 020956, Romania

[12] Univ Gen Hosp Larissa, Dept Cardiol, Terma Mazourlo 41110, Larissa, Greece

[13] Oklahoma State Univ, Ctr Hlth Sci, Sch Biomed Sci, Tulsa, OK USA

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2022年 / 72卷 / 11期

关键词：

EAAT; 1; 2; Glutamate; LDH; IL-1; beta; IL-10; DISEASE;

D O I：

10.1007/s12031-022-02078-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutamate, one of the most important excitatory neurotransmitters, acts as a signal transducer in peripheral tissues and endocrine cells. Excessive glutamate secretion has been shown to cause excitotoxicity and neurodegenerative disease. Cerebrolysin is a mixture of enzymatically treated peptides derived from pig brain including neurotrophic factors, like brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNTF). The present study investigated the protective effects of cerebrolysin on glutamate transporters (EAAT 1, EAAT 2) and cytokines (IL-1 beta and IL-10) activity in glutamate-mediated neurotoxicity. Primary cortex neuron culture was exposed to glutamate and successively treated with various cerebrolysin concentrations for 24 and 48 h. Our data showed that cerebrolysin primarily protects neurons by decreasing glutamate concentration in the synaptic cleft. In addition, Cerebrolysin can decrease oxidative stress and neuron cell damage by increasing antioxidant activity and decreasing inflammation cytokine levels.

引用

页码：2292 / 2302

页数：11

共 39 条

[1] Cerebrolysin prevents sleep deprivation induced memory impairment and oxidative stress [J].