EGFR-targeted therapy

被引：92

作者：

Vecchione, Loredana ^{[1
,2
,4
]}

Jacob, Bart ^{[1
,2
]}

Normanno, Nicola ^{[3
]}

Ciardiello, Fortunato ^{[4
]}

Tejpar, Sabine ^{[1
,2
]}

机构：

[1] Univ Hosp Gasthuisberg, Digest Oncol Unit, BE-3000 Louvain, Belgium

[2] Katholieke Univ Leuven, Ctr Human Genet, BE-3000 Louvain, Belgium

[3] INT Fdn Pascale, Cell Biol & Biotherapy Unit, I-80131 Naples, Italy

[4] Univ Naples 2, Div Med Oncol, Dept Expt & Clin Med & Surg F Magrassi & A Lanzar, I-80131 Naples, Italy

来源：

EXPERIMENTAL CELL RESEARCH | 2011年 / 317卷 / 19期

关键词：

EGFR signaling; Oncogenic dependency; Colorectal cancer; Anti-EGFR inhibitors; Molecular subgroups; Personalized cancer therapy; METASTATIC COLORECTAL-CANCER; GROWTH-FACTOR RECEPTOR; CETUXIMAB PLUS IRINOTECAN; GENE COPY NUMBER; CELL LUNG-CANCER; CLINICAL-PRACTICE; KRAS; MUTATIONS; PANITUMUMAB; BRAF;

D O I：

10.1016/j.yexcr.2011.08.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anti-Epidermal Growth Factor Receptor (EGFR) therapies have been recently developed for the treatment of multiple cancer types. At the time when they were introduced in clinical practice, there was little knowledge of the molecular bases of tumor sensitivity and resistance to these novel targeted compounds. By using the framework of anti-EGFR inhibitors as treatment for colorectal cancer patients, we will review the knowledge we have reached until now in improving the development of a personalized cancer therapy and we will try to indicate the future challenges this field will face in the future. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：2765 / 2771

页数：7

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