Clinical spectrum and IgG subclass analysis of anti-myelin oligodendrocyte glycoprotein antibody-associated syndromes: a multicenter study

被引：132

作者：

Mariotto, Sara ^{[1
,2
]}

Ferrari, Sergio ^{[1
]}

Monaco, Salvatore ^{[1
]}

Benedetti, Maria Donata ^{[1
]}

Schanda, Kathrin ^{[2
]}

Alberti, Daniela ^{[1
]}

Farinazzo, Alessia ^{[1
]}

Capra, Ruggero ^{[3
]}

Mancinelli, Chiara ^{[3
]}

De Rossi, Nicola ^{[3
]}

Bombardi, Roberto ^{[4
]}

Zuliani, Luigi ^{[5
]}

Zoccarato, Marco ^{[6
]}

Tanel, Raffaella ^{[7
]}

Bonora, Adriana ^{[8
]}

Turatti, Marco ^{[1
]}

Calabrese, Massimiliano ^{[1
]}

Polo, Alberto ^{[9
]}

Pavone, Antonino ^{[10
]}

Grazian, Luisa ^{[11
]}

Sechi, GianPietro ^{[12
]}

Sechi, Elia ^{[12
]}

Urso, Daniele ^{[12
]}

Delogu, Rachele ^{[12
]}

Janes, Francesco ^{[13
]}

Deotto, Luciano ^{[14
]}

Cadaldini, Morena ^{[15
]}

Bianchi, Maria Rachele ^{[16
]}

Cantalupo, Gaetano ^{[17
]}

Reindl, Markus ^{[2
]}

Gajofatto, Alberto ^{[1
]}

机构：

[1] Univ Verona, Dept Neurosci Biomed & Movement Sci, Neurol Unit, Verona, Italy

[2] Med Univ Innsbruck, Clin Dept Neurol, Innsbruck, Austria

[3] Spedali Civil Brescia, Multiple Sclerosis Ctr, Brescia, Italy

[4] St Bassano Hosp, Neurol Unit, Vicenza, Italy

[5] Ca Foncello Hosp, Neurol Unit, ULSS Marca Trevigiana 2, Treviso, Italy

[6] OSA, Neurol Unit, Padua, Italy

[7] Santa Chiara Hosp, Neurol Unit, Trento, Italy

[8] AOUI Verona, Ophthalmol Unit, Verona, Italy

[9] Mater Salutis Hosp, Neurol Unit, Verona, Italy

[10] Garibaldi Hosp, Neurol Unit, Catania, Italy

[11] Ca Foncello Hosp, Pediat Unit, ULSS Marca Trevigiana 2, Treviso, Italy

[12] Univ Sassari, Dept Clin & Expt Med, Neurol Unit, Sassari, Italy

[13] ASUIUD, Dept Neurosci, Neurol Unit, Udine, Italy

[14] AOUI Verona, Neurol Unit, Verona, Italy

[15] Multiple Sclerosis Ctr Este, Padua, Italy

[16] AAS2 Bassa Friulana Isontina, Neurol Unit, Gorizia, Italy

[17] Univ Verona, Child Neurol, Verona, Italy

来源：

JOURNAL OF NEUROLOGY | 2017年 / 264卷 / 12期

关键词：

Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies; Neuromyelitis optica spectrum disorders (NMOSD); Multiple sclerosis (MS); Optic neuritis; Myelitis; Acute disseminated encephalomyelitis (ADEM); NEUROMYELITIS-OPTICA PHENOTYPE; PEDIATRIC MULTIPLE-SCLEROSIS; MOG ANTIBODIES; DISSEMINATED ENCEPHALOMYELITIS; IMAGING CHARACTERISTICS; DISORDERS; CHILDREN; NMO; NEURITIS; DISEASE;

D O I：

10.1007/s00415-017-8635-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) recently emerged as a potential biomarker in patients with inflammatory demyelinating diseases of the central nervous system. We here compare the clinical and laboratory findings observed in a cohort of MOG-Ab seropositive and seronegative cases and describe IgG subclass analysis results. Consecutive serum samples referred to Verona University Neuropathology Laboratory for aquaporin-4 (AQP4)-Ab and/or MOG-Ab testing were analysed between March 2014 and May 2017. The presence of AQP4-Ab was determined using a cell-based assay. A live cell immunofluorescence assay was used for the detection of MOG-IgG and IgG subclass analysis. Among 454 analysed samples, 29 were excluded due to AQP4-Ab positivity or to the final demonstration of a disorder not compatible with MOG-Ab. We obtained clinical data in 154 out of 425 cases. Of these, 22 subjects resulted MOG-Ab positive. MOG-Ab positive patients were mainly characterised by the involvement of the optic nerve and/or spinal cord. Half of the cases presented relapses and the recovery was usually partial. Brain MRI was heterogeneous while short lesions were the prevalent observation on spinal cord MRI. MOG-Ab titre usually decreased in non-relapsing cases. In all MOG-IgG positive cases, we observed IgG1 antibodies, which were predominant in most subjects. IgG2 (5/22), IgG3 (9/22) and IgG4 (3/22) antibodies were also detectable. We confirm that MOG-Ab-related syndromes have distinct features in the spectrum of demyelinating conditions, and we describe the possible role of the different IgG subclasses in this condition.

引用

页码：2420 / 2430

页数：11

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