Skin Manifestations as Early Presenting Symptom of COVID-19 in Acute Myeloid Leukemia

Coronavirus infection in 2019 (COVID-19) is an acute respiratory infection caused by a coronavirus, and it has been associated with various organ involvement. However, there are few examples of COVID -19's unusual appearance in newly diagnosed acute myeloid leukaemia (AML). Through two case reports and a literature review, this report aims to provide an overview of cutaneous characteristics in COVID-19 individuals. In this study, we present two patients with AML who developed a diffuse maculopapular rash as an early indication of COVID-19. Our patients exhibited lung involvement and chest imaging characteristics consistent with COVID-19, as well as similar cutaneous manifestations. However, the COVID-19 RT-PCR became positive only in the first case at once. The various symptoms of COVID-19 are thought to be the result of an overwhelming immune response to coronavirus, which produces acute inflammation and tissue damage such as vasculitis and other skin lesions. Given the strategic importance of early COVID-19 diagnosis, particularly for malignant disorders, it is crucial to address the possibility of COVID-19 presenting with dermatologic manifestations.