Synthesis of the C1-C16 fragment of the ajudazols

被引：14

作者：

Egan, Ben A. ^{[1
]}

Paradowski, Michael ^{[2
]}

Thomas, Lynne H. ^{[3
]}

Marquez, Rodolfo ^{[1
]}

机构：

[1] Univ Glasgow, Sch Chem, Glasgow G12 8QQ, Lanark, Scotland

[2] Pfizer Global R&D, Sandwich CT13 9NJ, Kent, England

[3] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

TETRAHEDRON | 2011年 / 67卷 / 50期

基金：

英国工程与自然科学研究理事会;

关键词：

Ajudazol; Isobenzofuran; Oxidative rearrangement; CHONDROMYCES-CROCATUS; ALKENYLATION; COPPER;

D O I：

10.1016/j.tet.2011.10.036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the C1-C16 framework of the ajudazols has been achieved taking advantage of a highly selective isobenzofuran oxidative rearrangement and a key Stille coupling to introduce the key C14-C15 bond. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：9700 / 9707

页数：8

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