Cytotoxicity and lipid peroxidation-inhibiting activity of flavonoids

被引：80

作者：

Cos, P ^{[1
]}

Calomme, M ^{[1
]}

Sindambiwe, JB ^{[1
]}

De Bruyne, T ^{[1
]}

Cimanga, K ^{[1
]}

Pieters, L ^{[1
]}

Vlietinck, AJ ^{[1
]}

Vanden Berghe, D ^{[1
]}

机构：

[1] Univ Instelling Antwerp, Dept Pharmaceut Sci, B-2610 Wilrijk, Belgium

来源：

PLANTA MEDICA | 2001年 / 67卷 / 06期

关键词：

flavonoids; lipid peroxidation; cytotoxicity; MTT; structure-activity relationship;

D O I：

10.1055/s-2001-16472

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Thirty-five flavonoids of seven different types, namely isoflavonoids, chalcones, dihydroflavonols, flavanols, flavanones, flavones, and flavonols were investigated for their ability to inhibit ascorbate-induced microsomal lipid peroxidation and their cytotoxicity. For each activity a structure-activity relationship was established. Subsequently, an antioxidant selectivity index, i.e., the maximal non-toxic dose divided by the IC50 value for lipid peroxidation, was introduced. Kaempferol showed the highest antioxidant selectivity index of all flavonoids tested.

引用

页码：515 / 519

页数：5

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