Electrochemical Oxidative Regioselective C-H Cyanation of Imidazo[1,2-a]pyridines

被引：32

作者：

Cui, Ting ^{[1
]}

Zhan, Yanling ^{[1
]}

Dai, Changhui ^{[1
]}

Lin, Jun ^{[1
,2
]}

Liu, Ping ^{[1
,2
]}

Sun, Peipei ^{[1
]}

机构：

[1] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Peoples R China

[2] Nanjing Normal Univ, Changzhou Innovat & Dev Inst, Changzhou 213022, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 22期

基金：

中国国家自然科学基金;

关键词：

PALLADIUM-CATALYZED CYANATION; ARYL; FUNCTIONALIZATION; HETEROARENES; PROGRESS; NITRILE; HALIDES; MILD;

D O I：

10.1021/acs.joc.0c03026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Electrochemical oxidative regioselective C-H cyanation of imidazo[1,2-a]pyridines was developed using readily available TMSCN as the cyano source. The KH2PO4/K2HPO4 buffer was essential for this transformation. This protocol was compatible with a broad range of substituted imidazo[1,2-a]pyridines and provided the C3 cyanated products in moderate to excellent yields.

引用

页码：15897 / 15905

页数：9

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