Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway

被引：2

作者：

Li, Meng ^{[1
,2
]}

Zhang, Beibei ^{[1
,2
]}

Zeng, Mengnan ^{[1
,2
]}

Zhang, Jingke ^{[1
,2
]}

Zhang, Zhiguang ^{[1
,2
]}

Feng, Weisheng ^{[1
,2
]}

Zheng, Xiaoke ^{[1
,2
]}

机构：

[1] Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450046, Peoples R China

[2] Engn & Technol Ctr Chinese Med Dev Henan Prov, Zhengzhou 450046, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Lepidium apetalum Willd; seeds; benzoylamide derivatives; NRK-52e cell; LPS; Nrf2; Keap1; pathway; GLYCOSIDES;

D O I：

10.3390/molecules27030722

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new benzoylamide derivatives, lepidiumamide B-E (1-4), were isolated from the seeds of Lepidium apetalum Willd. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effects against NRK-52e cell injury induced by lipopolysaccharide (LPS) in vitro. These compounds showed significantly protective activity and ameliorated LPS-induced NRK52e cells via the Nrf2/Keap1 pathway. The discovery of these active compounds is important for the prevention and treatment of renalinjury.

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页数：8

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