Mammary tumors in HER-2/NEU mice are characterized by low content of estrogen receptors-a and absence of progesterone receptors

被引：7

作者：

Bershtein, LM ^{[1
]}

Alimova, IN ^{[1
]}

Tsyrlina, EV ^{[1
]}

Anisimov, VN ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, NN Petrov Inst Oncol, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 135卷 / 06期

关键词：

HER-2/neu gene; transgenic mice; breast cancer; steroid receptors;

D O I：

10.1023/A:1025437620749

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Transgenic mice carrying erbB2(HER-2)neu gene are characterized by high incidence of mammary adenocarcinoma. The content of estrogen receptor was no more than 10 fmol/mg protein in 8 of 14 studied tumors, while the content of progesterone receptors was even lower in all 14 studied tumors. Based on these data, we distinguish two subtypes of HER-2/neuadenocarcinomas in mice: ER+,PR- and ER-,PR-, which can be used for the development of new approaches to the treatment of receptor-negative mammary gland tumors.

引用

页码：580 / 581

页数：2

共 14 条

[1] Tyrosine kinase signalling in breast cancer - Tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer [J].

Andrechek, ER ;

Muller, WJ .

BREAST CANCER RESEARCH, 2000, 2 (03) :211-216

[2]

ANISIMOV VN, 2001, USPEKHI GERONTOL, P72

[3]

BERSHTEIN LM, 2000, HORMONAL CARCINOGENE

[4]

Brouillet JP, 2001, INT J CANCER, V95, P205, DOI 10.1002/1097-0215(20010720)95:4<205::AID-IJC1035>3.0.CO

[5]

2-Y

[6] HORMONAL-REGULATION OF C-ERBB-2 ONCOGENE EXPRESSION IN BREAST-CANCER CELLS [J].

DEBORTOLI, M ;

DATI, C ;

ANTONIOTTI, S ;

MAGGIORA, P ;

SAPEL, ML .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1992, 43 (1-3) :21-25

[7] Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer [J].

Dowsett, M .

[8]

Ferrero-Poüs M, 2000, CLIN CANCER RES, V6, P4745

[9]

Ménard S, 2000, CANCER RES, V60, P273

[10] Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer [J].

Nicholson, RI ;

Hutcheson, IR ;

Harper, ME ;

Knowlden, JM ;

Barrow, D ;

McClelland, RA ;

Jones, HE ;

Wakeling, AE ;

Gee, JMW .

← 1 2 →