Small berries as health-promoting ingredients: a review on anti-aging effects and mechanisms in Caenorhabditis elegans

被引：0

作者：

Li, Rong ^{[1
]}

Tao, Mingfang ^{[1
]}

Xu, Tingting ^{[1
]}

Pan, Siyi ^{[1
]}

Xu, Xiaoyun ^{[1
]}

Wu, Ting ^{[1
]}

机构：

[1] Huazhong Agr Univ, Coll Food Sci & Technol, Key Lab Environm Correlat Dietol, Minist Educ, Wuhan 430070, Peoples R China

来源：

FOOD & FUNCTION | 2022年 / 13卷 / 02期

关键词：

LIFE-SPAN EXTENSION; INCREASES STRESS RESISTANCE; BIOACTIVE COMPOUNDS; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS; SIGNALING PATHWAYS; NUCLEAR TRANSLOCATION; CALORIC RESTRICTION; CRANBERRY EXTRACT;

D O I：

10.1039/d1fo02184b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is an inevitable, irreversible, and complex process of damage accumulation and functional decline, increasing the risk of various chronic diseases. However, for now no drug can delay aging process nor cure aging-related diseases. Nutritional intervention is considered as a key and effective strategy to promote healthy aging and improve life quality. Small berries, as one of the most common and popular fruits, have been demonstrated to improve cognitive function and possess neuroprotective activities. However, the anti-aging effects of small berries have not been systematically elucidated yet. This review mainly focuses on small berries' anti-aging activity studies involving small berry types, active components, the utilized model organism Caenorhabditis elegans (C. elegans), related signaling pathways, and molecular mechanisms. The purpose of this review is to propose effective strategies to evaluate the anti-aging effects of small berries and provide guidance for the development of anti-aging supplements from small berries.

引用

页码：478 / 500

页数：23

共 192 条

[1] Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway [J].