Opioid poorly-responsive cancer pain. Part 3. Clinical strategies lo improve opioid responsiveness

被引：62

作者：

Mercadante, S

Portenoy, RK

机构：

[1] La Maddalena Canc Ctr, Anesthesia & Intens Care & Pain Relief Unit, I-90146 Palermo, Italy

[2] La Maddalena Canc Ctr, Palliat Care Unit, I-90146 Palermo, Italy

[3] Soc Assistenza Malato Oncol Terminale, Palermo, Italy

[4] Beth Israel Deaconess Med Ctr, Dept Pain Med & Palliat Care, New York, NY 10003 USA

来源：

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT | 2001年 / 21卷 / 04期

关键词：

cancer pain; neuropathic pain; opioid response; opioid toxicity; adjuvants; NMDA-antagonists; neural blockade; subcutaneous route; epidural route;

D O I：

10.1016/S0885-3924(01)00250-0

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Some pain syndromes may be difficult to treat due to a poor response to opioids. This situation demands a range of alternative measures, including the use of adjuvant drugs with independent effects, such as antidepressants, sodium channel-blocking agents, steroids and anti-inflammatory drugs (NSAIDs); drugs that reduce opioid side effects; and drugs that enhance analgesia produced by opioids, such as N-methyl-D-aspartate (NMDA) antagonists, calcium channel antagonists, and clonidine. Other approaches, including opioid trials, neural blockade when necessary and psychological interventions, also may be useful. (C) U.S. Cancer Pain Relief Committee, 2001.

引用

页码：338 / 354

页数：17

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