Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

被引：31

作者：

Lee, J ^{[1
]}

Kang, SU

Kim, SY

Kim, SE

Kang, MK

Jo, YJ

Kim, S

机构：

[1] Seoul Natl Univ, Coll Pharm, Med Chem Lab, Kwanak Ku, Seoul 151742, South Korea

[2] Sungkyunkwan Univ, ImaGene Co, Suwon 440746, South Korea

[3] Sungkyunkwan Univ, Natl Creative Res Initiat Ctr ARS Network, Suwon 440746, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)00095-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-activity relationship on a series of ester and hydroxamate analogues of methionyl and isoleucyl adenylate has been investigated through introducing linkers between the 1'-position of ribose and adenine surrogates as methionyl-tRNA. and isoleucyl-tRNA synthetase: inhibitors, respectively. The results indicate that ester analogue 23 was found to be a potent inhibitor of Escherichia coli methionyl-tRNA synthetase, and its interaction with the active site was proposed by a molecular modeling study. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：961 / 964

页数：4

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