Real-world long-term outcomes in multiple myeloma with VRD induction, Mel200-conditioned auto-HCT, and lenalidomide maintenance

被引：11

作者：

Gaballa, Mahmoud R. ^{[1
,2
]}

Ma, Junsheng ^{[3
]}

Tanner, Mark R. ^{[1
]}

Al-Juhaishi, Taha ^{[1
]}

Bashir, Qaiser ^{[1
]}

Srour, Samer A. ^{[1
]}

Saini, Neeraj Y. ^{[1
]}

Ramdial, Jeremy L. ^{[1
]}

Nieto, Yago ^{[1
]}

Murphy, Regan ^{[1
]}

Rezvani, Katayoun ^{[1
]}

Tang, Guilin ^{[4
]}

Lee, Hans C. ^{[5
]}

Patel, Krina K. ^{[5
]}

Kaufman, Gregory P. ^{[5
]}

Manasanch, Elisabet E. ^{[5
]}

Ullah, Muhammad R. ^{[6
]}

Kebriaei, Partow ^{[1
]}

Thomas, Sheeba K. ^{[5
]}

Weber, Donna M. ^{[5
]}

Orlowski, Robert Z. ^{[5
]}

Shpall, Elizabeth J. ^{[1
]}

Champlin, Richard E. ^{[1
]}

Qazilbash, Muzaffar H. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, 1515 Holcombe Blvd,Unit 0423, Houston, TX 77030 USA

[2] Massachusetts Gen Hosp, Bone Marrow Transplant & Cellular Immunotherapy P, Canc Ctr, Boston, MA 02114 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Div Pathol & Lab Med, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA

[6] Lahore Gen Hosp, Ameer Ud Din Med Coll, Lahore, Pakistan

来源：

LEUKEMIA & LYMPHOMA | 2022年 / 63卷 / 03期

关键词：

Multiple myeloma; transplantation; VRD; lenalidomide; outcomes; Mel200; STEM-CELL TRANSPLANTATION; NEWLY-DIAGNOSED MYELOMA; DEXAMETHASONE COMBINATION; INTERGROUPE FRANCOPHONE; CHROMOSOME-13; DELETION; 200 MG/M(2); OPEN-LABEL; BORTEZOMIB; THERAPY; CYTOGENETICS;

D O I：

10.1080/10428194.2021.1992763

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Standard-of-care for newly-diagnosed, autologous hematopoietic stem cell transplantation (auto-HCT)-eligible, multiple myeloma (MM) patients includes bortezomib, lenalidomide, and dexamethasone (VRD) induction followed by melphalan 200 mg/m(2) (Mel200)-conditioned auto-HCT and lenalidomide maintenance. We completed a retrospective case series assessing outcomes of 187 MM patients who received this regimen at our institution. The 100-day non-relapse mortality incidence was zero. Before auto-HCT, 9.6 and 52.9% of patients achieved a complete response (CR) or >= very good partial response (VGPR), respectively. At day-100 post-transplant, 29.4 and 74.9% had achieved a CR/stringent-CR (sCR) or >= VGPR, respectively. At the last evaluation, 57.2% of patients had CR/sCR and 87.1% had >= VGPR. Median follow-up, progression-free survival (PFS), and overall survival (OS) were 63.2, 50, and 101.7 months, respectively. The 5-year PFS and OS were 43.1 and 79%. High-risk cytogenetics was associated with worse outcomes. This study illustrates that VRD induction, Mel200-conditioned auto-HCT, and lenalidomide maintenance are associated with good outcomes in MM.

引用

页码：710 / 721

页数：12

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