Metal-Catalyzed Cross-Coupling Reactions on Azaindole Synthesis and Functionalization

被引：30
作者：
Sofia Santos, A. [1 ]
Mortinho, Ana C. [1 ]
Marques, M. Manuel B. [1 ]
机构：
[1] Univ Nova Lisboa, Dept Quim, LAQV REQUIMTE, Fac Ciencias & Tecnol, Campus Caparica, P-2829516 Caparica, Portugal
来源：
MOLECULES | 2018年 / 23卷 / 10期
关键词：
azaindole; metal-catalyzed; heterocycles; cross-coupling reactions; ONE-POT SYNTHESIS; C-H ACTIVATION; 7-AZAINDOLES; INDOLES; HETEROANNULATION; DESIGN; AMINOPYRIDINES; 4-AZAINDOLES; ANNULATION; INHIBITORS;
D O I：
10.3390/molecules23102673
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Azaindoles are rare in nature but extremely attractive for drug discovery programs. Azaindoles can be obtained by diverse methods, including those involving metal-catalyzed reactions. This important core has been fascinating the scientific community due to their challenging synthesis and relevant bioactivity. This paper highlights the diverse synthetic methodologies developed to date involving metal-catalyzed reaction to attain azaindoles and its functionalization.
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页数：16
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