The role of palliative interventional radiotherapy (brachytherapy) in esophageal cancer: An AIRO (Italian Association of Radiotherapy and Clinical Oncology) systematic review focused on dysphagia-free survival

被引：17

作者：

Lancellotta, Valentina ^{[1
]}

Cellini, Francesco ^{[1
]}

Fionda, Bruno ^{[1
]}

De Sanctis, Vitaliana ^{[2
]}

Vidali, Cristiana ^{[3
]}

Fusco, Vincenzo ^{[4
]}

Barbera, Fernando ^{[5
,6
]}

Gambacorta, Maria Antonietta ^{[1
,7
]}

Corvo, Renzo ^{[8
,9
]}

Magrini, Stefano Maria ^{[6
,10
]}

Tagliaferri, Luca ^{[1
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Diagnost Immagini Radioterapia Oncol, UOC Radioterapia Oncol, Rome, Italy

[2] Univ Roma La Sapienza, St Andrea Hosp, Fac Med & Psicol, Dept Radiat Oncol, Rome, Italy

[3] Azienda Sanitaria Univ Integrata Trieste ASUITS, Dept Radiat Oncol, Trieste, Italy

[4] Ctr Riferimento Oncol Regionale, Dept Radiat Oncol, Potenza, Italy

[5] Osped Civili Hosp, Radiat Oncol Dept, Brachytherapy Sect, Brescia, Italy

[6] Brescia Univ, Brescia, Italy

[7] Univ Cattolica Sacro Cuore, Ist Radiol, Rome, Italy

[8] Univ Genoa, IRCCS Osped Policlin San Martino, Radiat Oncol, Genoa, Italy

[9] Univ Genoa, Dept Hlth Sci, Genoa, Italy

[10] Osped Civili Hosp, Radiat Oncol Dept, Brescia, Italy

来源：

BRACHYTHERAPY | 2020年 / 19卷 / 01期

关键词：

Esophageal cancer; Interventional radiotherapy; Brachytherapy; Palliative; INTRALUMINAL BRACHYTHERAPY; MALIGNANT DYSPHAGIA; STENT PLACEMENT; EXTERNAL-BEAM; METAL STENT; GUIDELINES; CHEMOTHERAPY; MANAGEMENT; CARCINOMA; DIAGNOSIS;

D O I：

10.1016/j.brachy.2019.09.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PURPOSE: The aim of this review was to examine efficacy of palliative interventional radiotherapy (IRT) in esophageal cancer compared with other treatment in terms of dysphagia-free survival (DyFS) and safety. METHODS AND MATERIAL: A systematic research using PubMed, Scopus, and Cochrane library was performed to identify full articles evaluating the efficacy of IRT as palliation in patients with esophageal cancer. ClinicalTrials.gov was searched for ongoing or recently completed trials, and PROSPERO was searched for ongoing or recently completed systematic reviews. We analyzed only clinical study as full text of patients with symptomatic esophageal cancer treated with IRT alone or in combination with other treatment. Conference paper, survey, letter, editorial, book chapter, and review were excluded. Time restriction (1990-2018) as concerns the years of the publication was considered. The primary outcome was the duration of dysphagia relief (DyFS) after brachytherapy vs. other treatment (external-beam radiotherapy, photodynamic therapy, argon plasma coagulation, stent, and laser) during followup. Secondary outcomes included overall survival and adverse event rates. RESULTS: The literature search resulted in 554 articles. Sixty-six articles were assessed via full text for eligibility. Of these, 59 articles were excluded for various reasons, leaving seven randomized studies. The number of evaluated patients was 905 patients, and median age was 70.5 years. In the IRT group, the median DyFS was 99 days, the most relevant G3-G4 toxicity were fistula development and stenosis reported, respectively, in 8.3% and 12.2%; the overall median survival was 175.5 days. CONCLUSION: In conclusion, we provided evidence-based support that IRT is an effective and safe treatment option; therefore, its underuse is no longer justified. (C) 2020 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

引用

页码：104 / 110

页数：7

共 55 条

[1]

Allemani C, 2001, DIS ESOPHAGUS, V14, P120

[2] Fatal esophagoaortic fistula after placement of a self-expanding metal stent in a patient with esophageal carcinoma [J].