Proton-Pump Inhibitor as Palliative Care for Chemotherapy-Induced Gastroesophageal Reflux Disease in Pancreatic Cancer Patients

被引：11
|
作者：
Uwagawa, Tadashi [1 ]
Misawa, Takeyuki [1 ]
Iida, Tomonori [1 ]
Sakamoto, Taro [1 ]
Gocho, Takeshi [1 ]
Wakiyama, Shigeki [1 ]
Hirohara, Shoichi [1 ]
Yanaga, Katsuhiko [1 ]
机构：
[1] Jikei Univ, Sch Med, Dept Surg, Tokyo, Japan
来源：
JOURNAL OF PALLIATIVE MEDICINE | 2010年 / 13卷 / 07期
关键词：
RECOMMENDATIONS; GUIDELINES; THERAPY;
D O I：
10.1089/jpm.2009.0404
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
Relief of adverse events induced by chemotherapy is an important issue for patients, especially those with a poor prognosis, such as with pancreatic cancer. There are no reports of the relationship between gastroesophageal reflux disease (GERD) and chemotherapy, so we investigated the incidence of chemotherapy-induced GERD in patients undergoing treatment with gemcitabine or S-1 for pancreatic cancer and the effect of sodium rabeprazole (RPZ), a proton-pump inhibitor. GERD was diagnosed in 40% of the patients according to the Frequency Scale for Symptoms of GERD score, and RBZ therapy significantly improved their symptoms.
引用
收藏
页码：815 / 818
页数：4
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